The 2022 Nobel Prize in Chemistry for the development of click chemistry and bioorthogonal chemistry.
Biorthogonal chemistry
Chemoproteomics
Click chemistry
Metabolic labeling
Nobel Prize
Proteomics
Proximity labeling
Journal
Analytical and bioanalytical chemistry
ISSN: 1618-2650
Titre abrégé: Anal Bioanal Chem
Pays: Germany
ID NLM: 101134327
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
04
12
2022
accepted:
08
12
2022
pubmed:
6
1
2023
medline:
18
1
2023
entrez:
5
1
2023
Statut:
ppublish
Résumé
The 2022 Nobel Prize in Chemistry recognized the development of biorthogonal chemical ligation reactions known as click chemistry in biomedicine. This concept has catalyzed significant progress in sensing and diagnosis, chemical biology, materials chemistry, and drug discovery and delivery. In proteomics, the ability to incorporate a click tag into proteins has propelled development of powerful new methods for selective enrichment of protein complexes that inform understanding of protein networks. It also has had a strong influence on the ability to enrich for protein post-translational modifications. This feature article summarizes the impacts of biorthogonal click chemistry on proteomics.
Identifiants
pubmed: 36602567
doi: 10.1007/s00216-022-04483-9
pii: 10.1007/s00216-022-04483-9
doi:
Substances chimiques
Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
527-532Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM144090
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35GM144090
Pays : United States
Informations de copyright
© 2023. Springer-Verlag GmbH Germany, part of Springer Nature.
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