Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan.

Longevity Saccharomyces cerevisiae / metabolism Methionine / metabolism Signal Transduction
chronological aging eukaryotic longevity metabolic microenvironment metabolite exchange interactions

Journal

Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066

Informations de publication

Date de publication:
05 01 2023
Historique:
received: 22 03 2022
revised: 07 09 2022
accepted: 05 12 2022
entrez: 7 1 2023
pubmed: 8 1 2023
medline: 11 1 2023
Statut: ppublish

Résumé

Metabolism is deeply intertwined with aging. Effects of metabolic interventions on aging have been explained with intracellular metabolism, growth control, and signaling. Studying chronological aging in yeast, we reveal a so far overlooked metabolic property that influences aging via the exchange of metabolites. We observed that metabolites exported by young cells are re-imported by chronologically aging cells, resulting in cross-generational metabolic interactions. Then, we used self-establishing metabolically cooperating communities (SeMeCo) as a tool to increase metabolite exchange and observed significant lifespan extensions. The longevity of the SeMeCo was attributable to metabolic reconfigurations in methionine consumer cells. These obtained a more glycolytic metabolism and increased the export of protective metabolites that in turn extended the lifespan of cells that supplied them with methionine. Our results establish metabolite exchange interactions as a determinant of cellular aging and show that metabolically cooperating cells can shape the metabolic environment to extend their lifespan.

Identifiants

DOI: 10.1016/j.cell.2022.12.007 PMID: 36608659
pubmed: 36608659
pii: S0092-8674(22)01520-3
doi: 10.1016/j.cell.2022.12.007
pii:
doi:

Substances chimiques

Methionine AE28F7PNPL

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

63-79.e21

Subventions

Organisme : Wellcome Trust
ID : 200829/Z/16/Z
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests K.C. is currently employed by AstraZeneca.

Auteurs

Clara Correia-Melo (C)

The Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London NW1 1AT, UK; Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, UK; Department of Biochemistry, Charité - Universitätsmedizin Berlin, 10117 Berlin, Germany. Electronic address: claramelo85@gmail.com.

Stephan Kamrad (S)

The Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London NW1 1AT, UK.

Roland Tengölics (R)

Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre, Eötvös Loránd Research Network, Szeged 6726, Hungary; HCEMM-BRC Metabolic Systems Biology Lab, Szeged 6726, Hungary.

Christoph B Messner (CB)

The Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London NW1 1AT, UK; Precision Proteomics Center, Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, 7265 Davos, Switzerland.

Pauline Trebulle (P)

The Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London NW1 1AT, UK; The Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK.

StJohn Townsend (S)

The Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London NW1 1AT, UK; Department of Biochemistry, Charité - Universitätsmedizin Berlin, 10117 Berlin, Germany.

Sreejith Jayasree Varma (S)

Department of Biochemistry, Charité - Universitätsmedizin Berlin, 10117 Berlin, Germany.

Anja Freiwald (A)

Department of Biochemistry, Charité - Universitätsmedizin Berlin, 10117 Berlin, Germany; Core Facility - High Throughput Mass Spectrometry, Charité - Universitätsmedizin Berlin, 10117 Berlin, Germany.

Benjamin M Heineike (BM)

The Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London NW1 1AT, UK; The Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK; Quantitative Gene Expression Research Group, MRC London Institute of Medical Sciences (LMS), London W12 0HS, UK; Quantitative Gene Expression Research Group, Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, London SW2 2AZ, UK.

Kate Campbell (K)

Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, UK.

Lucía Herrera-Dominguez (L)

The Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London NW1 1AT, UK.

Simran Kaur Aulakh (S)

The Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London NW1 1AT, UK; The Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK.

Lukasz Szyrwiel (L)

The Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London NW1 1AT, UK; Department of Biochemistry, Charité - Universitätsmedizin Berlin, 10117 Berlin, Germany.

Jason S L Yu (JSL)

The Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London NW1 1AT, UK.

Aleksej Zelezniak (A)

The Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London NW1 1AT, UK; Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden; Randall Centre for Cell & Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL, UK; Institute of Biotechnology, Life Sciences Center, Vilnius University, Vilnius 10257, Lithuania.

Vadim Demichev (V)

The Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London NW1 1AT, UK; Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, UK; Department of Biochemistry, Charité - Universitätsmedizin Berlin, 10117 Berlin, Germany.

Michael Mülleder (M)

The Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London NW1 1AT, UK; Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, UK; Core Facility - High Throughput Mass Spectrometry, Charité - Universitätsmedizin Berlin, 10117 Berlin, Germany.

Balázs Papp (B)

Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre, Eötvös Loránd Research Network, Szeged 6726, Hungary; HCEMM-BRC Metabolic Systems Biology Lab, Szeged 6726, Hungary.

Mohammad Tauqeer Alam (MT)

Department of Biology, College of Science, United Arab Emirates University, P.O.Box 15551, Al-Ain, United Arab Emirates.

Markus Ralser (M)

The Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London NW1 1AT, UK; Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, UK; Department of Biochemistry, Charité - Universitätsmedizin Berlin, 10117 Berlin, Germany; The Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK. Electronic address: markus.ralser@charite.de.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Longévité › Cell-cell metabolite exchange creates a...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Saccharomyces › Saccharomyces cerevisiae › Cell-cell metabolite exchange creates a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés soufrés › Méthionine › Cell-cell metabolite exchange creates a...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Cell-cell metabolite exchange creates a...