Prostacyclin receptor agonists induce DUSP1 to inhibit pulmonary artery smooth muscle cell proliferation.
Humans
Pulmonary Artery
Receptors, Epoprostenol
/ metabolism
Familial Primary Pulmonary Hypertension
/ pathology
Pulmonary Arterial Hypertension
/ metabolism
Cell Proliferation
Endothelin-1
/ metabolism
Prostaglandins I
/ metabolism
Myocytes, Smooth Muscle
/ metabolism
Dual Specificity Phosphatase 1
/ metabolism
DUSP1
IP receptor
MAPK
Pulmonary arterial hypertension
Smooth muscle cells
Journal
Life sciences
ISSN: 1879-0631
Titre abrégé: Life Sci
Pays: Netherlands
ID NLM: 0375521
Informations de publication
Date de publication:
15 Feb 2023
15 Feb 2023
Historique:
received:
09
10
2022
revised:
08
12
2022
accepted:
02
01
2023
pubmed:
8
1
2023
medline:
1
2
2023
entrez:
7
1
2023
Statut:
ppublish
Résumé
Upregulated p38 PA-SMCs were treated with BMP2, ET-1, prostacyclin, and MRE-269, an active metabolite of selexipag, either alone or in combination. We quantified mRNA expressions using real-time quantitative polymerase chain reaction. Pulmonary artery specimens and PA-SMCs were obtained during lung transplantation in patients with PAH. Both prostacyclin and MRE-269 increased DUSP1 expression. Combined treatment with BMP2 and ET-1 induced cyclin D1 and DUSP1 expression and increased PA-SMC proliferation. MRE-269 attenuated BMP2/ET-1-induced cell proliferation. ET-1 increased DUSP1 expression in PA-SMCs from control patients but not in PA-SMCs from patients with PAH. This study showed that the p38
Identifiants
pubmed: 36608870
pii: S0024-3205(23)00006-1
doi: 10.1016/j.lfs.2023.121372
pii:
doi:
Substances chimiques
selexipag
5EXC0E384L
(4-((5,6-diphenylpyrazin-2-yl)(isopropyl)amino)butoxy)acetic acid
E9PC7N0DID
Receptors, Epoprostenol
0
Endothelin-1
0
Prostaglandins I
0
DUSP1 protein, human
EC 3.1.3.48
Dual Specificity Phosphatase 1
EC 3.1.3.48
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
121372Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare no conflict of interest.