Regulation of Mitochondrial Hydrogen Peroxide Availability by Protein S-glutathionylation.

Hydrogen Peroxide / metabolism Protein S / metabolism Mitochondria / metabolism Glutathione / metabolism Oxidation-Reduction
bioenergetics glutathionylation hydrogen peroxide mitochondria redox signaling

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
27 12 2022
Historique:
received: 16 11 2022
revised: 23 12 2022
accepted: 24 12 2022
entrez: 8 1 2023
pubmed: 9 1 2023
medline: 11 1 2023
Statut: epublish

Résumé

It has been four decades since protein S-glutathionylation was proposed to serve as a regulator of cell metabolism. Since then, this redox-sensitive covalent modification has been identified as a cell-wide signaling platform required for embryonic development and regulation of many physiological functions. Mitochondria use hydrogen peroxide (H The glutathione pool redox state is linked to the availability of H The biological significance of glutathionylation is rooted in redox status communication. The present review critically evaluates the experimental evidence supporting its role in negating mitochondrial H

Sections du résumé

BACKGROUND
It has been four decades since protein S-glutathionylation was proposed to serve as a regulator of cell metabolism. Since then, this redox-sensitive covalent modification has been identified as a cell-wide signaling platform required for embryonic development and regulation of many physiological functions.
SCOPE OF THE REVIEW
Mitochondria use hydrogen peroxide (H
MAJOR CONCLUSIONS
The glutathione pool redox state is linked to the availability of H
GENERAL SIGNIFICANCE
The biological significance of glutathionylation is rooted in redox status communication. The present review critically evaluates the experimental evidence supporting its role in negating mitochondrial H

Identifiants

DOI: 10.3390/cells12010107 PMID: 36611901 PMC: PMC9818751
pubmed: 36611901
pii: cells12010107
doi: 10.3390/cells12010107
pmc: PMC9818751
pii:
doi:

Substances chimiques

Hydrogen Peroxide BBX060AN9V
Protein S 0
Glutathione GAN16C9B8O

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Références

Antioxid Redox Signal. 2019 Dec;31(17):1272-1288
pubmed: 31317766
Biochemistry. 2003 Apr 15;42(14):4235-42
pubmed: 12680778
Biochim Biophys Acta. 2009 Feb;1793(2):427-38
pubmed: 19038292
Free Radic Biol Med. 2001 Jun 1;30(11):1191-212
pubmed: 11368918
Nature. 2016 Apr 7;532(7597):112-6
pubmed: 27027295
Free Radic Biol Med. 2014 Jul;72:149-55
pubmed: 24746616
Redox Biol. 2021 Sep;45:102044
pubmed: 34157640
Biochim Biophys Acta. 2013 Jan;1833(1):80-9
pubmed: 23069211
Eur J Pharm Sci. 2012 Aug 15;46(5):279-92
pubmed: 22484331
Biol Psychiatry. 2015 Nov 15;78(10):702-10
pubmed: 26003861
Nat Rev Mol Cell Biol. 2020 Jul;21(7):363-383
pubmed: 32231263
J Biol Chem. 2020 Nov 27;295(48):16207-16216
pubmed: 32747443
Proc Natl Acad Sci U S A. 2021 May 18;118(20):
pubmed: 33972444
Free Radic Res. 2011 Jan;45(1):29-36
pubmed: 21110783
Biochem J. 2017 Nov 9;474(22):3799-3815
pubmed: 28963348
Nature. 2014 Nov 20;515(7527):431-435
pubmed: 25383517
J Biol Chem. 2001 Aug 10;276(32):30374-80
pubmed: 11397793
J Biol Chem. 2014 May 23;289(21):14812-28
pubmed: 24727547
Arch Biochem Biophys. 2021 Jun 15;704:108890
pubmed: 33894196
Nature. 2019 Sep;573(7773):291-295
pubmed: 31462775
Antioxidants (Basel). 2022 Jul 29;11(8):
pubmed: 36009207
Free Radic Biol Med. 2021 Nov 1;175:184-192
pubmed: 34481042
Cell Metab. 2016 Apr 12;23(4):725-34
pubmed: 27076081
J Cell Biol. 2017 Dec 4;216(12):4073-4090
pubmed: 29150539
Immunity. 2012 Dec 14;37(6):1037-49
pubmed: 23159440
Basic Res Cardiol. 2020 Aug 3;115(5):53
pubmed: 32748289
Biochim Biophys Acta. 2009 Nov;1790(11):1486-500
pubmed: 19376195
Redox Biol. 2018 Jul;17:367-376
pubmed: 29857311
Antioxid Redox Signal. 2011 Jul 1;15(1):233-70
pubmed: 21235352
Cell Metab. 2005 Jun;1(6):409-14
pubmed: 16054090
Antioxidants (Basel). 2019 Jul 26;8(8):
pubmed: 31357416
Biomed Pharmacother. 2019 Oct;118:108940
pubmed: 31382130
Antioxid Redox Signal. 2020 Apr 20;32(12):884-905
pubmed: 31931592
Curr Opin Chem Biol. 2022 Dec;71:102221
pubmed: 36223700
Proc Natl Acad Sci U S A. 1976 Jul;73(7):2275-9
pubmed: 7783
Free Radic Biol Med. 2021 Aug 20;172:1-8
pubmed: 34052343
Free Radic Biol Med. 2013 May;58:109-17
pubmed: 23376233
J Biol Chem. 2004 Nov 12;279(46):47939-51
pubmed: 15347644
Trends Biochem Sci. 2013 Dec;38(12):592-602
pubmed: 24120033
J Mol Cell Cardiol. 2014 Aug;73:2-9
pubmed: 24512843
Redox Biol. 2020 May;32:101450
pubmed: 32146156
Free Radic Biol Med. 2011 Dec 1;51(11):2108-17
pubmed: 21983434
Antioxid Redox Signal. 2022 May;36(13-15):864-884
pubmed: 34155914
Biochemistry. 2008 Oct 21;47(42):11144-57
pubmed: 18816065
J Biol Chem. 2010 Jan 29;285(5):3168-80
pubmed: 19940158
Antioxid Redox Signal. 2015 Sep 20;23(9):734-46
pubmed: 25891126
FEBS Lett. 1997 Oct 13;416(1):15-8
pubmed: 9369223
J Biol Chem. 2001 Jul 13;276(28):26269-75
pubmed: 11297543
J Biol Chem. 2021 Jan-Jun;296:100377
pubmed: 33837731
Free Radic Biol Med. 2013 Dec;65:1201-1208
pubmed: 24056031
Free Radic Biol Med. 2018 May 20;120:204-216
pubmed: 29578070
Front Cell Dev Biol. 2014 Nov 17;2:68
pubmed: 25453035
Free Radic Biol Med. 2016 Aug;97:501-512
pubmed: 27394173
J Biol Chem. 2001 Dec 21;276(51):47763-6
pubmed: 11684673
Redox Biol. 2013 Dec 19;2:123-39
pubmed: 24455476
Cancer Metab. 2021 May 10;9(1):22
pubmed: 33971967
J Biol Chem. 2014 Dec 26;289(52):36125-39
pubmed: 25362663
Biochemistry. 2008 Jan 8;47(1):473-8
pubmed: 18081316
Int J Mol Med. 2010 Jul;26(1):95-9
pubmed: 20514427
Sci Signal. 2013 Jan 01;6(256):rs1
pubmed: 23281369
Redox Biol. 2016 Aug;8:110-8
pubmed: 26773874
Biol Chem. 2015 May;396(5):523-37
pubmed: 25581756
Cell. 2014 Mar 13;156(6):1235-1246
pubmed: 24630725
Antioxidants (Basel). 2022 Oct 01;11(10):
pubmed: 36290696
Biochem J. 2009 Jan 1;417(1):1-13
pubmed: 19061483
Proteomics. 2017 Mar;17(6):
pubmed: 28044432
Free Radic Biol Med. 2023 Jan;194:123-130
pubmed: 36462627
Antioxid Redox Signal. 2005 Jul-Aug;7(7-8):999-1010
pubmed: 15998254
Cell Metab. 2014 May 6;19(5):757-66
pubmed: 24561260
Biochim Biophys Acta Gen Subj. 2017 Aug;1861(8):1960-1969
pubmed: 28506882
Am J Cancer Res. 2022 Jan 15;12(1):48-67
pubmed: 35141004
Biochem J. 2015 Apr 15;467(2):271-80
pubmed: 25643703
Redox Biol. 2022 Aug 5;55:102429
pubmed: 35961099
Free Radic Biol Med. 2013 Aug;61:161-9
pubmed: 23567190
Circ Res. 2011 Sep 16;109(7):750-7
pubmed: 21817160
Free Radic Biol Med. 2019 Apr;134:268-281
pubmed: 30597195
J Biol Chem. 2003 May 30;278(22):19603-10
pubmed: 12649289
Geroscience. 2021 Oct;43(5):2395-2412
pubmed: 34480713
Atherosclerosis. 2015 Jul;241(1):69-78
pubmed: 25966442
Free Radic Biol Med. 2013 Dec;65:742-749
pubmed: 23938402
J Biol Chem. 2014 Mar 21;289(12):8312-25
pubmed: 24515115
J Proteome Res. 2019 Apr 5;18(4):1806-1818
pubmed: 30831029
Biochem J. 2015 Jul 1;469(1):25-32
pubmed: 25891661
Philos Trans R Soc Lond B Biol Sci. 2005 Dec 29;360(1464):2335-45
pubmed: 16321804
Free Radic Biol Med. 2016 Dec;101:334-347
pubmed: 27743883
Cell Metab. 2011 Oct 5;14(4):537-44
pubmed: 21982713
J Biol Chem. 1994 Sep 9;269(36):22459-62
pubmed: 8077188
J Biol Chem. 2008 Sep 5;283(36):24801-15
pubmed: 18611857
J Biol Chem. 2003 Oct 24;278(43):42588-95
pubmed: 12915401
Nat Metab. 2022 Jun;4(6):651-662
pubmed: 35760871
Redox Rep. 2012;17(2):63-71
pubmed: 22564349
Antioxid Redox Signal. 2009 May;11(5):1059-81
pubmed: 19119916
Free Radic Res. 2016;50(2):126-42
pubmed: 26291534
Curr Opin Pharmacol. 2007 Aug;7(4):381-91
pubmed: 17662654
Chem Biol Interact. 2019 Feb 1;299:151-162
pubmed: 30537466
Biochemistry. 1998 Nov 10;37(45):15835-41
pubmed: 9843389
Can J Cardiol. 2021 Jan;37(1):140-150
pubmed: 32640211
J Mol Med (Berl). 2011 Nov;89(11):1137-48
pubmed: 21769686
J Neurosci. 2004 Sep 8;24(36):7771-8
pubmed: 15356188
Biochem J. 1980 Jul 15;190(1):125-30
pubmed: 7447929
Antioxid Redox Signal. 2012 Mar 15;16(6):471-5
pubmed: 22136616
Redox Rep. 2020 Dec;25(1):87-94
pubmed: 32993466
Redox Biol. 2018 Apr;14:509-521
pubmed: 29101900
Antioxidants (Basel). 2022 Oct 17;11(10):
pubmed: 36290766
Free Radic Biol Med. 2017 May;106:302-314
pubmed: 28242228
Antioxid Redox Signal. 2009 Nov;11(11):2807-50
pubmed: 19476414
Nat Commun. 2017 Apr 04;8:14835
pubmed: 28374771
Methods Enzymol. 2013;528:3-25
pubmed: 23849856
J Neurosci. 2004 Sep 8;24(36):7779-88
pubmed: 15356189
Redox Biol. 2018 May;15:216-227
pubmed: 29274570
Protein J. 2010 May;29(4):250-6
pubmed: 20490902
Redox Biol. 2020 Aug;35:101484
pubmed: 32184060
FEBS Lett. 1983 Feb 7;152(1):114-8
pubmed: 6840271
Philos Trans R Soc Lond B Biol Sci. 1985 Dec 17;311(1152):617-31
pubmed: 2869521
Adv Enzyme Regul. 1985;23:217-37
pubmed: 3907304
Free Radic Biol Med. 2015 Jan;78:1-10
pubmed: 25451644
Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3505-10
pubmed: 11904414
Expert Opin Drug Metab Toxicol. 2011 Jul;7(7):891-910
pubmed: 21557709
PLoS One. 2018 Feb 14;13(2):e0192801
pubmed: 29444156
Nat Rev Mol Cell Biol. 2022 Jul;23(7):499-515
pubmed: 35190722
Antioxid Redox Signal. 2008 Nov;10(11):1941-88
pubmed: 18774901
Free Radic Biol Med. 2015 Dec;89:972-81
pubmed: 26476010
Biochim Biophys Acta. 2012 Jun;1817(6):851-62
pubmed: 21924235
J Clin Med. 2017 May 03;6(5):
pubmed: 28467362

Auteurs

Ryan J Mailloux (RJ)

The School of Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, Sainte-Anne-de-Bellevue, QC H9X 3V9, Canada.
ORCID: 0000-0003-3986-9830

Cathryn Grayson (C)

The School of Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, Sainte-Anne-de-Bellevue, QC H9X 3V9, Canada.

Olivia Koufos (O)

The School of Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, Sainte-Anne-de-Bellevue, QC H9X 3V9, Canada.
ORCID: 0000-0002-1814-5625

Articles similaires

Pathogenic mitochondrial DNA mutations inhibit melanoma metastasis.

Spencer D Shelton, Sara House, Luiza Martins Nascentes Melo et al.
1.00
DNA, Mitochondrial Humans Melanoma Mutation Neoplasm Metastasis

A dual role for PSIP1/LEDGF in T cell acute lymphoblastic leukemia.

Lisa Demoen, Filip Matthijssens, Lindy Reunes et al.
1.00
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Animals Mice Humans Cell Line, Tumor

Membrane potential stimulates ADP import and ATP export by the mitochondrial ADP/ATP carrier due to its positively charged binding site.

Vasiliki Mavridou, Martin S King, Andre Bazzone et al.
1.00
Adenosine Triphosphate Adenosine Diphosphate Mitochondrial ADP, ATP Translocases Binding Sites Mitochondria

High mitochondrial DNA levels accelerate lung adenocarcinoma progression.

Mara Mennuni, Stephen E Wilkie, Pauline Michon et al.
1.00
DNA, Mitochondrial Animals Adenocarcinoma of Lung Disease Progression Mice

Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › Regulation of Mitochondrial Hydrogen Peroxide...
questionsmedicales.fr › Facteurs biologiques › Inhibiteurs des facteurs de la coagulation sanguine › Protéine S › Regulation of Mitochondrial Hydrogen Peroxide...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Regulation of Mitochondrial Hydrogen Peroxide...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Oligopeptides › Glutathion › Regulation of Mitochondrial Hydrogen Peroxide...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Regulation of Mitochondrial Hydrogen Peroxide...