Effects of Oleuropein and Hydroxytyrosol on Inflammatory Mediators: Consequences on Inflammaging.
hydroxytyrosol
inflammaging
nutraceutical
oleuropein
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
26 Dec 2022
26 Dec 2022
Historique:
received:
15
11
2022
revised:
14
12
2022
accepted:
21
12
2022
entrez:
8
1
2023
pubmed:
9
1
2023
medline:
11
1
2023
Statut:
epublish
Résumé
Aging is associated with a low-grade, systemic inflammatory state defined as "inflammaging", ruled by the loss of proper regulation of the immune system leading to the accumulation of pro-inflammatory mediators. Such a condition is closely connected to an increased risk of developing chronic diseases. A number of studies demonstrate that olive oil phenolic compound oleuropein and its derivative hydroxytyrosol contribute to modulating tissue inflammation and oxidative stress, thus becoming attractive potential candidates to be used in the context of nutraceutical interventions, in order to ameliorate systemic inflammation in aging subjects. In this review, we aim to summarize the available data about the anti-inflammatory properties of oleuropein and hydroxytyrosol, discussing them in the light of molecular pathways involved in the synthesis and release of inflammatory mediators in inflammaging.
Identifiants
pubmed: 36613822
pii: ijms24010380
doi: 10.3390/ijms24010380
pmc: PMC9820525
pii:
doi:
Substances chimiques
oleuropein
2O4553545L
3,4-dihydroxyphenylethanol
10597-60-1
Inflammation Mediators
0
Antioxidants
0
Iridoid Glucosides
0
Olive Oil
0
Phenylethyl Alcohol
ML9LGA7468
Iridoids
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Int Immunopharmacol. 2017 Feb;43:147-155
pubmed: 27998828
Cells. 2022 Jan 21;11(3):
pubmed: 35159168
Clin Interv Aging. 2018 Apr 26;13:757-772
pubmed: 29731617
J Leukoc Biol. 2006 Aug;80(2):376-82
pubmed: 16707559
Rejuvenation Res. 2012 Feb;15(1):71-81
pubmed: 22236145
Front Biosci. 2008 May 01;13:5094-107
pubmed: 18508572
Endocr Metab Immune Disord Drug Targets. 2018;18(1):36-50
pubmed: 29141574
J Nat Prod. 2013 Jun 28;76(6):1113-20
pubmed: 23758110
J Food Biochem. 2019 Aug;43(8):e12941
pubmed: 31368572
Curr Res Pharmacol Drug Discov. 2021 Feb 05;2:100016
pubmed: 34909651
Front Physiol. 2020 Jul 02;11:694
pubmed: 32714204
Nat Immunol. 2020 Jun;21(6):615-625
pubmed: 32251403
Exp Gerontol. 2011 Aug;46(8):694-702
pubmed: 21570457
Ageing Res Rev. 2022 May;77:101596
pubmed: 35219904
Molecules. 2016 Dec 16;21(12):
pubmed: 27999296
Clin Rev Allergy Immunol. 2021 Sep 18;:
pubmed: 34536213
Eur Rev Med Pharmacol Sci. 2020 Jun;24(11):6455-6462
pubmed: 32572943
J Cell Mol Med. 2022 Apr;26(8):2337-2350
pubmed: 35278036
Cell Biol Int. 2021 Oct;45(10):1999-2016
pubmed: 34245637
J Agric Food Chem. 2015 Feb 25;63(7):2098-105
pubmed: 25613688
Arch Immunol Ther Exp (Warsz). 2016 Apr;64(2):111-26
pubmed: 26658771
Nutrients. 2021 Jan 22;13(2):
pubmed: 33499113
Mediators Inflamm. 2014;2014:406514
pubmed: 24948847
Int J Mol Cell Med. 2020 Summer;9(3):224-233
pubmed: 33274185
Int J Pharm. 2020 Aug 30;586:119515
pubmed: 32544520
Nutrition. 2005 Mar;21(3):389-94
pubmed: 15797683
Cells. 2021 Sep 28;10(10):
pubmed: 34685542
Nat Rev Cardiol. 2018 Sep;15(9):505-522
pubmed: 30065258
F1000Res. 2019 Jan 28;8:
pubmed: 30755793
Cell Signal. 2012 Apr;24(4):835-45
pubmed: 22182507
Molecules. 2019 Sep 05;24(18):
pubmed: 31492013
Sci Adv. 2020 Jul 29;6(31):eabb0806
pubmed: 32832688
Mol Nutr Food Res. 2017 Dec;61(12):
pubmed: 28815947
Nat Rev Immunol. 2021 Jul;21(7):411-425
pubmed: 33514947
Oxid Med Cell Longev. 2016;2016:1580967
pubmed: 27547291
J Ethnopharmacol. 2021 Jun 28;274:114079
pubmed: 33798661
J Biol Chem. 2008 Jun 27;283(26):17777-88
pubmed: 18387943
Aging Cell. 2021 Feb;20(2):e13290
pubmed: 33512769
Exp Dermatol. 2019 Jul;28(7):809-815
pubmed: 31001893
Fac Rev. 2021 Sep 07;10:71
pubmed: 34557875
Front Pharmacol. 2022 Jun 02;13:877709
pubmed: 35721185
BMC Med. 2015 Jul 13;13:161
pubmed: 26166298
Mediators Inflamm. 2015;2015:137823
pubmed: 25709154
Endocrinology. 2010 Oct;151(10):4894-907
pubmed: 20810567
Front Cell Dev Biol. 2020 May 21;8:365
pubmed: 32671059
Atherosclerosis. 2014 Jan;232(1):17-24
pubmed: 24401212
Int J Mol Sci. 2016 May 31;17(6):
pubmed: 27258251
Front Pharmacol. 2012 Jul 19;3:119
pubmed: 22833723
Aging Dis. 2011 Dec;2(6):449-65
pubmed: 22396894
Cell Tissue Res. 2012 Jan;347(1):155-75
pubmed: 21626289
J Immunol. 2008 May 1;180(9):5771-7
pubmed: 18424693
Mol Biol Rep. 2020 Feb;47(2):1371-1379
pubmed: 31873871
Biomed Pharmacother. 2021 Sep;141:111816
pubmed: 34126350
Redox Biol. 2016 Dec;10:233-242
pubmed: 27810738
Cells. 2021 Jul 27;10(8):
pubmed: 34440675
Pharmacol Res. 2019 Dec;150:104487
pubmed: 31610229
J Immunol. 2010 Sep 15;185(6):3694-701
pubmed: 20713883
Int Immunopharmacol. 2017 Jul;48:187-195
pubmed: 28525856
Cytokine. 1995 May;7(4):372-9
pubmed: 8589268
Front Immunol. 2021 Oct 05;12:733566
pubmed: 34675924
Immunobiology. 2016 Dec;221(12):1374-1377
pubmed: 27475990
Food Funct. 2018 Jun 20;9(6):3220-3234
pubmed: 29781491
Int J Clin Exp Pathol. 2015 Apr 01;8(4):3441-50
pubmed: 26097528
Mol Nutr Food Res. 2019 Nov;63(21):e1900019
pubmed: 31393642
Turk J Pharm Sci. 2021 Sep 1;18(4):420-429
pubmed: 34496482
Immunol Rev. 2018 Jan;281(1):8-27
pubmed: 29247995
Front Aging Neurosci. 2019 Jan 17;10:439
pubmed: 30705627
Biomed Pharmacother. 2021 Oct;142:112073
pubmed: 34463261
Mol Cancer. 2017 Apr 13;16(1):79
pubmed: 28407774
Periodontol 2000. 2015 Oct;69(1):142-59
pubmed: 26252407
Int J Mol Sci. 2018 Feb 28;19(3):
pubmed: 29495598
Int J Mol Med. 2018 Aug;42(2):1034-1043
pubmed: 29767261
Front Immunol. 2018 Jan 10;8:1960
pubmed: 29375577
Mol Med Rep. 2018 Mar;17(3):4035-4042
pubmed: 29286133
J Endocr Soc. 2020 Feb 20;4(2):bvz039
pubmed: 32099951
Inflammation. 2022 Feb;45(1):297-307
pubmed: 34613549
Molecules. 2021 Jan 31;26(3):
pubmed: 33572633
Front Cell Dev Biol. 2021 Feb 11;9:628157
pubmed: 33644065
Front Immunol. 2019 Jun 20;10:1412
pubmed: 31281320
Front Immunol. 2018 Apr 09;9:586
pubmed: 29686666
Acta Pharm. 2021 Mar 1;71(1):131-141
pubmed: 32697745
Naunyn Schmiedebergs Arch Pharmacol. 2009 Jun;379(6):581-6
pubmed: 19198806
Molecules. 2018 Dec 05;23(12):
pubmed: 30563131
Genes Dev. 2020 Dec 1;34(23-24):1565-1576
pubmed: 33262144
J Nutr Biochem. 2013 Aug;24(8):1513-9
pubmed: 23477728
Clin Nutr. 2005 Oct;24(5):780-4
pubmed: 15908056
Biomol Concepts. 2018 May 30;9(1):64-79
pubmed: 29856726
Biomed Res Int. 2020 Jan 8;2020:1315202
pubmed: 31998777
Clin Rev Allergy Immunol. 2022 Jan 15;:
pubmed: 35031957
Oxid Med Cell Longev. 2017;2017:6437467
pubmed: 28298952
Free Radic Biol Med. 2019 Apr;134:702-707
pubmed: 30654017
Lab Invest. 2007 Nov;87(11):1077-91
pubmed: 17724448
BMC Microbiol. 2016 Jan 16;16:9
pubmed: 26772806
J Exp Med. 2020 Jan 6;217(1):
pubmed: 31611251
Lancet Healthy Longev. 2021 May;2(5):e290-e300
pubmed: 36098136
Biomed Res Int. 2020 Jun 22;2020:5036572
pubmed: 32685494
J Leukoc Biol. 2012 Oct;92(4):753-64
pubmed: 22782966
Int Immunopharmacol. 2016 Jun;35:29-42
pubmed: 27016717
Int J Immunopathol Pharmacol. 2022 Jan-Dec;36:3946320221086084
pubmed: 35410513
Endocr Metab Immune Disord Drug Targets. 2018;18(1):14-22
pubmed: 29141570
Cell Host Microbe. 2018 Apr 11;23(4):570
pubmed: 29649447
Front Immunol. 2020 Jun 03;11:947
pubmed: 32582147
J Leukoc Biol. 2004 Feb;75(2):163-89
pubmed: 14525967
Molecules. 2019 May 24;24(10):
pubmed: 31137753
Cell Mol Biol (Noisy-le-grand). 2019 Jan 31;65(1):52-55
pubmed: 30782294
Acta Cir Bras. 2021 Feb 15;36(1):e360107
pubmed: 33605309
Int Rev Cell Mol Biol. 2016;326:133-74
pubmed: 27572128
Nat Immunol. 2021 Jun;22(6):687-698
pubmed: 33986548
Biomedicines. 2021 Jul 30;9(8):
pubmed: 34440125
IUBMB Life. 2020 Oct;72(10):2121-2132
pubmed: 32710811
Mol Nutr Food Res. 2016 Mar;60(3):530-41
pubmed: 26603374
Nutrients. 2022 Feb 23;14(5):
pubmed: 35267924
Eur J Pharmacol. 2010 Dec 1;648(1-3):188-94
pubmed: 20826143
Respir Res. 2001;2(2):66-70
pubmed: 11686867
Cell Cycle. 2014;13(23):3628-35
pubmed: 25483060
FEBS J. 2020 Jan;287(1):43-52
pubmed: 31529582
J Med Food. 2018 Mar;21(3):302-305
pubmed: 29099642
Int J Mol Sci. 2019 Jun 06;20(11):
pubmed: 31174250
Appl Microbiol. 1973 Nov;26(5):777-82
pubmed: 4762397
Biomol Concepts. 2017 Sep 26;8(3-4):143-153
pubmed: 28841566
Cold Spring Harb Perspect Biol. 2019 Mar 1;11(3):
pubmed: 29661791
J Tissue Eng Regen Med. 2020 Dec;14(12):1841-1857
pubmed: 33010113
Front Pharmacol. 2021 Mar 24;12:617314
pubmed: 33841147
Int J Mol Sci. 2017 Oct 30;18(11):
pubmed: 29084133
Int J Mol Sci. 2019 Sep 10;20(18):
pubmed: 31510091
Mol Nutr Food Res. 2016 Feb;60(2):242-55
pubmed: 26502315
Molecules. 2015 Feb 11;20(2):2903-21
pubmed: 25679050
Food Funct. 2016 Jan;7(1):301-7
pubmed: 26469183
Biomed Res Int. 2013;2013:912431
pubmed: 24066302
Enzyme Res. 2011;2011:537821
pubmed: 21876792
Nutrients. 2017 Apr 15;9(4):
pubmed: 28420140
Cells. 2020 Feb 19;9(2):
pubmed: 32093046
Front Public Health. 2020 Nov 26;8:574111
pubmed: 33324597
Biomed Pharmacother. 2019 Jan;109:2472-2481
pubmed: 30551508
Adv Clin Exp Med. 2015 Mar-Apr;24(2):213-8
pubmed: 25931351
Nat Rev Immunol. 2018 Sep;18(9):545-558
pubmed: 29921905
Trends Mol Med. 2010 May;16(5):238-46
pubmed: 20444648
Chemosphere. 2011 Aug;84(7):888-93
pubmed: 21741071
Int J Mol Sci. 2019 Oct 10;20(20):
pubmed: 31658594
Inflamm Regen. 2019 Jun 6;39:12
pubmed: 31182982
Nat Rev Immunol. 2012 Feb 17;12(3):180-90
pubmed: 22343569
Cells. 2021 May 26;10(6):
pubmed: 34073434
Front Oncol. 2018 May 15;8:160
pubmed: 29868481
Ann N Y Acad Sci. 2000 Jun;908:244-54
pubmed: 10911963
Physiol Rev. 2012 Apr;92(2):689-737
pubmed: 22535895
Antioxidants (Basel). 2020 Feb 10;9(2):
pubmed: 32050687
Pharmacol Res. 2019 May;143:58-72
pubmed: 30853597
Toxicol In Vitro. 2015 Aug;29(5):933-7
pubmed: 25866079
J Agric Food Chem. 2018 Jul 25;66(29):7643-7654
pubmed: 29945446
Exp Gerontol. 2018 May;105:4-9
pubmed: 29111233
Int J Mol Sci. 2020 Feb 13;21(4):
pubmed: 32070025
Sci Pharm. 2010;78(2):133-54
pubmed: 21179340
Front Immunol. 2020 Jul 28;11:1558
pubmed: 32849528
Methods Cell Biol. 2011;103:203-20
pubmed: 21722805
J Immunol Res. 2016;2016:8426874
pubmed: 27493973
Genes (Basel). 2013 Mar 26;4(2):101-33
pubmed: 24705157
Biochimie. 2021 Feb;181:52-64
pubmed: 33278558
Poult Sci. 2022 Jan;101(1):101516
pubmed: 34784517
Oxid Med Cell Longev. 2022 Jun 3;2022:8673728
pubmed: 35693707
Immun Ageing. 2019 May 21;16:11
pubmed: 31139232
J Inflamm Res. 2018 Oct 30;11:407-419
pubmed: 30464573
Naunyn Schmiedebergs Arch Pharmacol. 2017 Mar;390(3):245-252
pubmed: 27928616
Ageing Res Rev. 2008 Apr;7(2):83-105
pubmed: 17964225
PLoS One. 2013;8(3):e57622
pubmed: 23516412
Antioxidants (Basel). 2021 Oct 06;10(10):
pubmed: 34679712
Trends Endocrinol Metab. 2017 Mar;28(3):199-212
pubmed: 27789101
Food Funct. 2017 Oct 18;8(10):3737-3744
pubmed: 28952621
Antioxidants (Basel). 2022 Mar 24;11(4):
pubmed: 35453308
Ageing Res Rev. 2021 Nov;71:101422
pubmed: 34391943
Exp Gerontol. 2018 May;105:10-18
pubmed: 29275161