PlrA (MSMEG_5223) is an essential polar growth regulator in Mycobacterium smegmatis.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2023
2023
Historique:
received:
16
09
2022
accepted:
27
12
2022
entrez:
12
1
2023
pubmed:
13
1
2023
medline:
17
1
2023
Statut:
epublish
Résumé
Mycobacteria expand their cell walls at the cell poles in a manner that is not well described at the molecular level. In this study, we identify a new polar factor, PlrA, that is involved in restricting peptidoglycan metabolism to the cell poles in Mycobacterium smegmatis. We establish that only the N-terminal membrane domain of PlrA is essential. We show that depletion of plrA pheno-copies depletion of polar growth factor Wag31, and that PlrA is involved in regulating the Wag31 polar foci.
Identifiants
pubmed: 36634117
doi: 10.1371/journal.pone.0280336
pii: PONE-D-22-25807
pmc: PMC9836265
doi:
Substances chimiques
Bacterial Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0280336Subventions
Organisme : NIAID NIH HHS
ID : R01 AI148917
Pays : United States
Organisme : NIGMS NIH HHS
ID : R15 GM131317
Pays : United States
Informations de copyright
Copyright: © 2023 Quintanilla et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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