Predicting executive functioning from functional brain connectivity: network specificity and age effects.
aging
cognitive abilities
fMRI
machine learning
out-of-sample prediction
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
24 05 2023
24 05 2023
Historique:
received:
13
09
2022
revised:
07
12
2022
accepted:
08
12
2022
pmc-release:
12
01
2024
medline:
2
6
2023
pubmed:
13
1
2023
entrez:
12
1
2023
Statut:
ppublish
Résumé
Healthy aging is associated with altered executive functioning (EF). Earlier studies found age-related differences in EF performance to be partially accounted for by changes in resting-state functional connectivity (RSFC) within brain networks associated with EF. However, it remains unclear which role RSFC in EF-associated networks plays as a marker for individual differences in EF performance. Here, we investigated to what degree individual abilities across 3 different EF tasks can be predicted from RSFC within EF-related, perceptuo-motor, whole-brain, and random networks separately in young and old adults. Specifically, we were interested if (i) young and old adults differ in predictability depending on network or EF demand level (high vs. low), (ii) an EF-related network outperforms EF-unspecific networks when predicting EF abilities, and (iii) this pattern changes with demand level. Both our uni- and multivariate analysis frameworks analyzing interactions between age × demand level × networks revealed overall low prediction accuracies and a general lack of specificity regarding neurobiological networks for predicting EF abilities. This questions the idea of finding markers for individual EF performance in RSFC patterns and calls for future research replicating the current approach in different task states, brain modalities, different, larger samples, and with more comprehensive behavioral measures.
Identifiants
pubmed: 36635227
pii: 6986358
doi: 10.1093/cercor/bhac520
pmc: PMC10233269
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
6495-6507Subventions
Organisme : NIMH NIH HHS
ID : R01 MH074457
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Références
Neuroimage. 2015 Jan 1;104:69-78
pubmed: 25281800
Trends Cogn Sci. 2021 Dec;25(12):1021-1032
pubmed: 34625348
Brain Imaging Behav. 2009;3(2):142-153
pubmed: 19536354
Neuroimage. 2000 Jun;11(6 Pt 1):805-21
pubmed: 10860804
J Neurosci. 2017 Mar 8;37(10):2734-2745
pubmed: 28174333
Neuroimage. 2018 Oct 15;180(Pt B):534-546
pubmed: 29024792
Front Aging Neurosci. 2019 Sep 04;11:234
pubmed: 31555124
J Neurosci Methods. 2010 Mar 30;187(2):254-62
pubmed: 19945485
Trends Cogn Sci. 2010 Apr;14(4):172-9
pubmed: 20171926
Neurosci Biobehav Rev. 2018 Jul;90:400-410
pubmed: 29730485
Curr Dir Psychol Sci. 2012 Feb;21(1):8-14
pubmed: 22773897
Neuroimage. 2015 Feb 1;106:428-40
pubmed: 25463462
Annu Rev Psychol. 2009;60:173-96
pubmed: 19035823
Cereb Cortex. 2023 Mar 10;33(6):2682-2703
pubmed: 35697648
PLoS One. 2017 Aug 24;12(8):e0183250
pubmed: 28837692
Brain Struct Funct. 2015;220(3):1739-57
pubmed: 24718622
Hum Brain Mapp. 2020 Aug 15;41(12):3186-3197
pubmed: 32364670
Cereb Cortex. 2021 May 10;31(6):2822-2833
pubmed: 33447841
Brain Struct Funct. 2019 Jun;224(5):1845-1869
pubmed: 31037397
Nat Neurosci. 2013 Jul;16(7):832-7
pubmed: 23799476
J Neurosci. 2007 Feb 28;27(9):2349-56
pubmed: 17329432
Front Hum Neurosci. 2010 Nov 22;4:217
pubmed: 21151373
Nature. 2022 May;605(7911):E11
pubmed: 35534626
Neuroimage. 2021 Jul 15;235:117963
pubmed: 33813007
Annu Rev Psychol. 2013;64:135-68
pubmed: 23020641
Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11678-83
pubmed: 26324898
J Int Neuropsychol Soc. 2004 Mar;10(2):301-3
pubmed: 15012851
Neuroimage. 2016 Jun;133:321-330
pubmed: 27001500
J Cogn Neurosci. 2015 Dec;27(12):2462-76
pubmed: 26351864
Neuroimage. 2019 Jul 15;195:320-332
pubmed: 30953834
Behav Brain Res. 2012 Apr 21;230(1):192-200
pubmed: 22348896
Neuroimage. 2019 Jun;193:35-45
pubmed: 30831310
J Abnorm Psychol. 2001 Feb;110(1):40-8
pubmed: 11261398
Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13040-5
pubmed: 19620724
Front Aging Neurosci. 2020 Jun 12;12:177
pubmed: 32595490
J Clin Exp Neuropsychol. 2005 Jul;27(5):599-609
pubmed: 16019636
J Neurosci. 2013 Oct 9;33(41):16249-61
pubmed: 24107956
Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13848-53
pubmed: 16945915
Brain Connect. 2016 Mar;6(2):164-8
pubmed: 26650337
Neuroimage. 2007 Jul 1;36(3):511-21
pubmed: 17499520
Netw Neurosci. 2017 Jun 01;1(2):192-207
pubmed: 29911673
Neuroimage. 2019 Dec;203:116157
pubmed: 31494250
Annu Rev Neurosci. 2015 Jul 8;38:433-47
pubmed: 25938726
Acta Neurobiol Exp (Wars). 1972;32(2):615-56
pubmed: 4627626
Neuroimage. 2018 Oct 15;180(Pt B):406-416
pubmed: 28823827
Neuron. 2016 Oct 19;92(2):544-554
pubmed: 27693256
Trends Neurosci. 2000 Oct;23(10):475-83
pubmed: 11006464
Sci Rep. 2021 May 11;11(1):9942
pubmed: 33976234
Neuroimage. 2018 Jan 15;165:138-147
pubmed: 29030105
Nat Commun. 2018 Jul 18;9(1):2807
pubmed: 30022026
Cortex. 2020 Nov;132:441-459
pubmed: 33065515
Neuroscientist. 2014 Oct;20(5):432-8
pubmed: 25030990
Cereb Cortex. 2021 Oct 1;31(11):5263-5274
pubmed: 34145442
Neuroimage. 2011 May 15;56(2):455-75
pubmed: 20656037
Neuron. 2011 Nov 17;72(4):665-78
pubmed: 22099467
J Cogn Neurosci. 2007 Jun;19(6):1021-32
pubmed: 17536972
Nat Neurosci. 2015 Nov;18(11):1664-71
pubmed: 26457551
Nat Protoc. 2017 Mar;12(3):506-518
pubmed: 28182017
Neuroimage. 2020 Jun;213:116687
pubmed: 32126299
PLoS Biol. 2019 Mar 25;17(3):e2007032
pubmed: 30908490
Neuroimage. 2012 Mar;60(1):830-46
pubmed: 22178808
Neuroimage. 2014 Jul 15;95:232-47
pubmed: 24657355
Neuroimage. 2005 May 1;25(4):1325-35
pubmed: 15850749
JAMA Psychiatry. 2020 May 1;77(5):534-540
pubmed: 31774490
Front Neurosci. 2012 Oct 16;6:152
pubmed: 23087608
Neuroimage. 2014 Apr 15;90:449-68
pubmed: 24389422