Single-cell RNA sequencing identifies a population of human liver-type ILC1s.

Humans Lymphocytes Immunity, Innate Endothelial Cells Killer Cells, Natural Liver Transcription Factors Sequence Analysis, RNA
CP: Immunology ILC1 TGF-β cirrhotic liver cross-tissue ILC1 human group 1 ILC innate lymphoid cell liver ILC1 liver environment natural killer cell

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
31 01 2023
Historique:
received: 22 03 2021
revised: 30 09 2022
accepted: 15 12 2022
pubmed: 15 1 2023
medline: 7 2 2023
entrez: 14 1 2023
Statut: ppublish

Résumé

Group 1 innate lymphoid cells (ILCs) comprise a heterogeneous family of cytotoxic natural killer (NK) cells and ILC1s. We identify a population of "liver-type" ILC1s with transcriptional, phenotypic, and functional features distinct from those of conventional and liver-resident NK cells as well as from other previously described human ILC1 subsets. LT-ILC1s are CD49a

Identifiants

DOI: 10.1016/j.celrep.2022.111937 PMID: 36640314 PMC: PMC9950534
pubmed: 36640314
pii: S2211-1247(22)01838-1
doi: 10.1016/j.celrep.2022.111937
pmc: PMC9950534
mid: NIHMS1870503
pii:
doi:

Substances chimiques

Transcription Factors 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

111937

Subventions

Organisme : NCI NIH HHS
ID : L30 CA199447
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA255860
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA208353
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016058
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI145997
Pays : United States
Organisme : NCI NIH HHS
ID : F30 CA250244
Pays : United States
Organisme : NCI NIH HHS
ID : F30 CA236063
Pays : United States

Informations de copyright

Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Références

FEBS Lett. 2001 Jul 27;502(1-2):1-3
pubmed: 11478937
Front Immunol. 2019 Sep 11;10:2180
pubmed: 31572388
Nat Commun. 2021 Oct 6;12(1):5841
pubmed: 34615883
Immunity. 2019 Feb 19;50(2):505-519.e4
pubmed: 30770247
Gut. 2019 May;68(5):916-927
pubmed: 29970455
Immunity. 2017 May 16;46(5):756-757
pubmed: 28514676
Blood. 2014 Jul 31;124(5):700-9
pubmed: 24778151
Gut. 2022 Jun;71(6):1161-1175
pubmed: 34340996
Cell. 2014 Apr 10;157(2):340-356
pubmed: 24725403
Immunity. 2010 Jun 25;32(6):803-14
pubmed: 20620944
Nat Protoc. 2021 Aug;16(8):3802-3835
pubmed: 34215862
Nat Immunol. 2013 Mar;14(3):221-9
pubmed: 23334791
Sci Immunol. 2022 Apr 8;7(70):eabi8642
pubmed: 35394814
Cell Rep. 2016 Jul 12;16(2):379-391
pubmed: 27373165
Front Immunol. 2019 Jun 04;10:1255
pubmed: 31214196
Nat Immunol. 2011 Sep 11;12(11):1055-62
pubmed: 21909091
Cell. 2018 Aug 23;174(5):1054-1066
pubmed: 30142344
Cell. 2017 Mar 9;168(6):1086-1100.e10
pubmed: 28283063
Mol Ecol Resour. 2013 Jul;13(4):663-73
pubmed: 23617785
Immunity. 2016 May 17;44(5):1127-39
pubmed: 27156386
Elife. 2019 Aug 08;8:
pubmed: 31393266
Sci Rep. 2016 May 23;6:26157
pubmed: 27210614
Immunity. 2017 May 16;46(5):758-759
pubmed: 28514677
Proc Natl Acad Sci U S A. 2021 Jul 6;118(27):
pubmed: 34183415
Cell. 2017 Nov 2;171(4):795-808.e12
pubmed: 29056343
Front Immunol. 2019 Sep 20;10:2235
pubmed: 31616419
Front Immunol. 2019 Apr 30;10:946
pubmed: 31114585
Gut. 2007 Feb;56(2):243-52
pubmed: 16840505
Front Immunol. 2019 Aug 29;10:2078
pubmed: 31555287
PLoS One. 2017 Dec 19;12(12):e0188649
pubmed: 29261670
Eur J Immunol. 2017 Aug;47(8):1280-1294
pubmed: 28613415
Immunity. 2018 Sep 18;49(3):464-476.e4
pubmed: 30193847
Front Immunol. 2019 Jul 03;10:1502
pubmed: 31333651
Nature. 2009 Feb 5;457(7230):722-5
pubmed: 18978771
Elife. 2014 Jan 01;3:e01659
pubmed: 24714492
Front Immunol. 2016 Jan 07;6:646
pubmed: 27004067
PLoS Pathog. 2017 May 15;13(5):e1006373
pubmed: 28505204
Sci Rep. 2015 Jul 30;5:12490
pubmed: 26223896
Blood Adv. 2019 Nov 26;3(22):3674-3687
pubmed: 31765481
Nat Commun. 2018 Oct 22;9(1):4383
pubmed: 30348985
J Hepatol. 2018 Sep;69(3):654-665
pubmed: 29758330
Cancer Immunol Res. 2019 Sep;7(9):1535-1546
pubmed: 31311791
Front Immunol. 2012 Apr 09;3:72
pubmed: 22566953
Sci Rep. 2017 Mar 13;7:44356
pubmed: 28287163
Trends Immunol. 2019 Oct;40(10):909-921
pubmed: 31500958
J Immunol. 2016 Jul 1;197(1):78-84
pubmed: 27226093
Elife. 2021 Feb 08;10:
pubmed: 33554861
Immunity. 2013 Apr 18;38(4):769-81
pubmed: 23453631
Immunity. 2017 Jan 17;46(1):148-161
pubmed: 27986455
PLoS One. 2016 Jul 25;11(7):e0159217
pubmed: 27454769
Signal Transduct Target Ther. 2017;2:
pubmed: 29201496
Immunity. 2021 Feb 9;54(2):276-290.e5
pubmed: 33434494
Nat Immunol. 2017 Sep;18(9):1004-1015
pubmed: 28759001
Nature. 2019 Apr;568(7752):405-409
pubmed: 30944470
Nat Immunol. 2009 Jan;10(1):66-74
pubmed: 19029905
Sci Immunol. 2020 Oct 16;5(52):
pubmed: 33067380

Auteurs

Benjamin Krämer (B)

Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany; German Center for Infection Research (DZIF), 53127 Bonn, Germany. Electronic address: benjamin.kraemer@ukbonn.de.

Ansel P Nalin (AP)

Medical Scientist Training Program, The Ohio State University, Columbus, OH 43210, USA; Biomedical Sciences Graduate Program, The Ohio State University, Columbus, OH 43210, USA.

Feiyang Ma (F)

Molecular Cell and Developmental Biology, College of Life Sciences, University of California Los Angeles, Los Angeles, CA 90095, USA.

Sarah Eickhoff (S)

Institute of Experimental Oncology (IEO), Medical Faculty, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany.

Philipp Lutz (P)

Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany; German Center for Infection Research (DZIF), 53127 Bonn, Germany.

Sonia Leonardelli (S)

Institute of Experimental Oncology (IEO), Medical Faculty, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany.

Felix Goeser (F)

Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany; German Center for Infection Research (DZIF), 53127 Bonn, Germany.

Claudia Finnemann (C)

Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany; German Center for Infection Research (DZIF), 53127 Bonn, Germany.

Gudrun Hack (G)

Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany; German Center for Infection Research (DZIF), 53127 Bonn, Germany.

Jan Raabe (J)

Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany; German Center for Infection Research (DZIF), 53127 Bonn, Germany.

Michael ToVinh (M)

Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany; German Center for Infection Research (DZIF), 53127 Bonn, Germany.

Sarah Ahmad (S)

Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany; German Center for Infection Research (DZIF), 53127 Bonn, Germany.

Christoph Hoffmeister (C)

Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany; German Center for Infection Research (DZIF), 53127 Bonn, Germany.

Kim M Kaiser (KM)

Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany; German Center for Infection Research (DZIF), 53127 Bonn, Germany.

Steffen Manekeller (S)

Department of Surgery, University of Bonn, 53127 Bonn, Germany.

Vittorio Branchi (V)

Department of Surgery, University of Bonn, 53127 Bonn, Germany.

Tobias Bald (T)

Institute of Experimental Oncology (IEO), Medical Faculty, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany.

Michael Hölzel (M)

Institute of Experimental Oncology (IEO), Medical Faculty, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany.

Robert Hüneburg (R)

Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany.

Hans Dieter Nischalke (HD)

Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany.

Alexander Semaan (A)

Department of Surgery, University of Bonn, 53127 Bonn, Germany.

Bettina Langhans (B)

Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany; German Center for Infection Research (DZIF), 53127 Bonn, Germany.

Dominik J Kaczmarek (DJ)

Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany.

Brooke Benner (B)

Biomedical Sciences Graduate Program, The Ohio State University, Columbus, OH 43210, USA.

Matthew R Lordo (MR)

Medical Scientist Training Program, The Ohio State University, Columbus, OH 43210, USA; Biomedical Sciences Graduate Program, The Ohio State University, Columbus, OH 43210, USA.

Jesse Kowalski (J)

Nationwide Children's Hospital, Columbus, OH, USA.

Adam Gerhardt (A)

College of Medicine, University of Cincinnati, Cincinnati, OH 45221, USA.

Jörg Timm (J)

Institute of Virology, University of Duesseldorf, 40225 Düsseldorf, Germany.

Marieta Toma (M)

Department of Pathology, University of Bonn, 53127 Bonn, Germany.

Raphael Mohr (R)

Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany.

Andreas Türler (A)

General and Visceral Surgery, Johanniter Hospital, 53113 Bonn, Germany.

Arthur Charpentier (A)

Department of Otorhinolaryngology/Head and Neck Surgery, University of Bonn, 53127 Bonn, Germany; Department of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University of Cologne, 50931 Cologne, Germany.

Tobias van Bremen (T)

Department of Otorhinolaryngology/Head and Neck Surgery, University of Bonn, 53127 Bonn, Germany.

Georg Feldmann (G)

Department of Internal Medicine III, University of Bonn, 53127 Bonn, Germany.

Arne Sattler (A)

Clinic for Surgery, Transplant Immunology Lab, Charité University Hospital Berlin, 10117 Berlin, Germany.

Katja Kotsch (K)

Clinic for Surgery, Transplant Immunology Lab, Charité University Hospital Berlin, 10117 Berlin, Germany.

Ali T Abdallah (AT)

Interdisciplinary Center for Clinical Research, RWTH Aachen University, 52074 Aachen, Germany.

Christian P Strassburg (CP)

Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany.

Ulrich Spengler (U)

Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany; German Center for Infection Research (DZIF), 53127 Bonn, Germany.

William E Carson (WE)

Division of Surgical Oncology, Department of Surgery, Comprehensive Cancer Center and The James Cancer Hospital and Solove Research Institute, Columbus, OH 43210, USA.

Bethany L Mundy-Bosse (BL)

Division of Hematology, Department of Internal Medicine, Comprehensive Cancer Center, The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA.

Matteo Pellegrini (M)

Molecular Cell and Developmental Biology, College of Life Sciences, University of California Los Angeles, Los Angeles, CA 90095, USA.

Timothy E O'Sullivan (TE)

Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 900953, USA.

Aharon G Freud (AG)

Department of Pathology, Comprehensive Cancer Center, The James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA. Electronic address: aharon.freud@osumc.edu.

Jacob Nattermann (J)

Department of Internal Medicine I, University of Bonn, 53127 Bonn, Germany; German Center for Infection Research (DZIF), 53127 Bonn, Germany.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Single-cell RNA sequencing identifies a...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Single-cell RNA sequencing identifies a...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité innée › Single-cell RNA sequencing identifies a...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Single-cell RNA sequencing identifies a...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Cellules tueuses naturelles › Single-cell RNA sequencing identifies a...
questionsmedicales.fr › Système digestif › Foie › Single-cell RNA sequencing identifies a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Single-cell RNA sequencing identifies a...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ARN › Single-cell RNA sequencing identifies a...