Biotransformation of the Novel Myeloperoxidase Inhibitor AZD4831 in Preclinical Species and Humans.

Humans Rats Mice Animals Dogs Peroxidase Glucuronides Biotransformation Chromatography, High Pressure Liquid Amines

Journal

Drug metabolism and disposition: the biological fate of chemicals
ISSN: 1521-009X
Titre abrégé: Drug Metab Dispos
Pays: United States
ID NLM: 9421550

Informations de publication

Date de publication:
04 2023
Historique:
received: 30 08 2022
accepted: 15 12 2022
pubmed: 19 1 2023
medline: 28 3 2023
entrez: 18 1 2023
Statut: ppublish

Résumé

We report herein an in-depth analysis of the metabolism of the novel myeloperoxidase inhibitor AZD4831 ((

Identifiants

DOI: 10.1124/dmd.122.001099 PMID: 36653117
pubmed: 36653117
pii: dmd.122.001099
doi: 10.1124/dmd.122.001099
doi:

Substances chimiques

AZD4831 0
Peroxidase EC 1.11.1.7
Glucuronides 0
Amines 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

464-479

Subventions

Organisme : NIGMS NIH HHS
ID : T32 GM008763
Pays : United States

Informations de copyright

Copyright © 2023 by The Author(s).

Auteurs

Ulrik Jurva (U)

Drug Metabolism and Pharmacokinetics, Research and Early Development, Cardiovascular, Renal and Metabolism (U.J., L.W., A-S.S., A.E., X.L., V.S.G.); Drug Metabolism and Pharmacokinetics, Research and Early Development, Respiratory and Immunology (C.L.), Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (T.A., J.S., K.W., T.I.), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden; and Formerly of AstraZeneca (L.W., C.A.) ulrik.jurva@astrazeneca.com.

Lars Weidolf (L)

Drug Metabolism and Pharmacokinetics, Research and Early Development, Cardiovascular, Renal and Metabolism (U.J., L.W., A-S.S., A.E., X.L., V.S.G.); Drug Metabolism and Pharmacokinetics, Research and Early Development, Respiratory and Immunology (C.L.), Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (T.A., J.S., K.W., T.I.), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden; and Formerly of AstraZeneca (L.W., C.A.).

Ann-Sofie Sandinge (AS)

Drug Metabolism and Pharmacokinetics, Research and Early Development, Cardiovascular, Renal and Metabolism (U.J., L.W., A-S.S., A.E., X.L., V.S.G.); Drug Metabolism and Pharmacokinetics, Research and Early Development, Respiratory and Immunology (C.L.), Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (T.A., J.S., K.W., T.I.), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden; and Formerly of AstraZeneca (L.W., C.A.).

Carina Leandersson (C)

Drug Metabolism and Pharmacokinetics, Research and Early Development, Cardiovascular, Renal and Metabolism (U.J., L.W., A-S.S., A.E., X.L., V.S.G.); Drug Metabolism and Pharmacokinetics, Research and Early Development, Respiratory and Immunology (C.L.), Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (T.A., J.S., K.W., T.I.), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden; and Formerly of AstraZeneca (L.W., C.A.).

Anja Ekdahl (A)

Drug Metabolism and Pharmacokinetics, Research and Early Development, Cardiovascular, Renal and Metabolism (U.J., L.W., A-S.S., A.E., X.L., V.S.G.); Drug Metabolism and Pharmacokinetics, Research and Early Development, Respiratory and Immunology (C.L.), Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (T.A., J.S., K.W., T.I.), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden; and Formerly of AstraZeneca (L.W., C.A.).

Xue-Qing Li (XQ)

Drug Metabolism and Pharmacokinetics, Research and Early Development, Cardiovascular, Renal and Metabolism (U.J., L.W., A-S.S., A.E., X.L., V.S.G.); Drug Metabolism and Pharmacokinetics, Research and Early Development, Respiratory and Immunology (C.L.), Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (T.A., J.S., K.W., T.I.), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden; and Formerly of AstraZeneca (L.W., C.A.).

Thomas Antonsson (T)

Drug Metabolism and Pharmacokinetics, Research and Early Development, Cardiovascular, Renal and Metabolism (U.J., L.W., A-S.S., A.E., X.L., V.S.G.); Drug Metabolism and Pharmacokinetics, Research and Early Development, Respiratory and Immunology (C.L.), Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (T.A., J.S., K.W., T.I.), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden; and Formerly of AstraZeneca (L.W., C.A.).

Johan Sundell (J)

Drug Metabolism and Pharmacokinetics, Research and Early Development, Cardiovascular, Renal and Metabolism (U.J., L.W., A-S.S., A.E., X.L., V.S.G.); Drug Metabolism and Pharmacokinetics, Research and Early Development, Respiratory and Immunology (C.L.), Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (T.A., J.S., K.W., T.I.), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden; and Formerly of AstraZeneca (L.W., C.A.).

Kristina Westerlund (K)

Drug Metabolism and Pharmacokinetics, Research and Early Development, Cardiovascular, Renal and Metabolism (U.J., L.W., A-S.S., A.E., X.L., V.S.G.); Drug Metabolism and Pharmacokinetics, Research and Early Development, Respiratory and Immunology (C.L.), Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (T.A., J.S., K.W., T.I.), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden; and Formerly of AstraZeneca (L.W., C.A.).

Carl Amilon (C)

Drug Metabolism and Pharmacokinetics, Research and Early Development, Cardiovascular, Renal and Metabolism (U.J., L.W., A-S.S., A.E., X.L., V.S.G.); Drug Metabolism and Pharmacokinetics, Research and Early Development, Respiratory and Immunology (C.L.), Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (T.A., J.S., K.W., T.I.), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden; and Formerly of AstraZeneca (L.W., C.A.).

Tord Inghardt (T)

Drug Metabolism and Pharmacokinetics, Research and Early Development, Cardiovascular, Renal and Metabolism (U.J., L.W., A-S.S., A.E., X.L., V.S.G.); Drug Metabolism and Pharmacokinetics, Research and Early Development, Respiratory and Immunology (C.L.), Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (T.A., J.S., K.W., T.I.), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden; and Formerly of AstraZeneca (L.W., C.A.).

V Sashi Gopaul (VS)

Drug Metabolism and Pharmacokinetics, Research and Early Development, Cardiovascular, Renal and Metabolism (U.J., L.W., A-S.S., A.E., X.L., V.S.G.); Drug Metabolism and Pharmacokinetics, Research and Early Development, Respiratory and Immunology (C.L.), Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (T.A., J.S., K.W., T.I.), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden; and Formerly of AstraZeneca (L.W., C.A.).

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Biotransformation of the Novel Myeloperoxidase...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Biotransformation of the Novel Myeloperoxidase...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Biotransformation of the Novel Myeloperoxidase...
questionsmedicales.fr › Eucaryotes › Animaux › Biotransformation of the Novel Myeloperoxidase...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Carnivora › Pinnipedia › Canidae › Chiens › Biotransformation of the Novel Myeloperoxidase...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Peroxidases › Myeloperoxidase › Biotransformation of the Novel Myeloperoxidase...
questionsmedicales.fr › Glucides › Oses acides › Acides uroniques › Glucuronates › Glucuronides › Biotransformation of the Novel Myeloperoxidase...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Biotransformation › Biotransformation of the Novel Myeloperoxidase...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Chromatographie en phase liquide à haute performance › Biotransformation of the Novel Myeloperoxidase...
questionsmedicales.fr › Composés chimiques organiques › Amines › Biotransformation of the Novel Myeloperoxidase...