Integrated single-cell profiling dissects cell-state-specific enhancer landscapes of human tumor-infiltrating CD8

Humans CD8-Positive T-Lymphocytes Neoplasms / genetics Regulatory Sequences, Nucleic Acid Gene Expression Regulation Chromatin / genetics Lymphocytes, Tumor-Infiltrating Enhancer Elements, Genetic
CRISPR activation CRISPR interference T cell exhaustion cancer immunology chromatin accessibility enhancer gene regulation single-cell ATAC-seq tumor-infiltrating T cells

Journal

Molecular cell
ISSN: 1097-4164
Titre abrégé: Mol Cell
Pays: United States
ID NLM: 9802571

Informations de publication

Date de publication:
16 02 2023
Historique:
received: 20 07 2022
revised: 22 11 2022
accepted: 23 12 2022
pubmed: 20 1 2023
medline: 25 2 2023
entrez: 19 1 2023
Statut: ppublish

Résumé

Despite extensive studies on the chromatin landscape of exhausted T cells, the transcriptional wiring underlying the heterogeneous functional and dysfunctional states of human tumor-infiltrating lymphocytes (TILs) is incompletely understood. Here, we identify gene-regulatory landscapes in a wide breadth of functional and dysfunctional CD8

Identifiants

DOI: 10.1016/j.molcel.2022.12.029 PMID: 36657444
pubmed: 36657444
pii: S1097-2765(22)01212-6
doi: 10.1016/j.molcel.2022.12.029
pii:
doi:

Substances chimiques

Chromatin 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

622-636.e10

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Dania Riegel (D)

Leibniz Institute for Immunotherapy (LIT), 93053 Regensburg, Germany.

Elena Romero-Fernández (E)

Leibniz Institute for Immunotherapy (LIT), 93053 Regensburg, Germany.

Malte Simon (M)

Faculty of Biosciences, Heidelberg University, 69120 Heidelberg, Germany; Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

Akinbami Raphael Adenugba (AR)

Department of Surgery, University Hospital Regensburg, 93053 Regensburg, Germany.

Katrin Singer (K)

Department of Internal Medicine III, University Hospital Regensburg, 93053 Regensburg, Germany; Department of Otorhinolaryngology, University Hospital Regensburg, 93053 Regensburg, Germany.

Roman Mayr (R)

Department of Urology, Caritas St. Josef Medical Centre, University of Regensburg, 93053 Regensburg, Germany.

Florian Weber (F)

Institute of Pathology, University of Regensburg, 93053 Regensburg, Germany.

Mark Kleemann (M)

Leibniz Institute for Immunotherapy (LIT), 93053 Regensburg, Germany.

Charles D Imbusch (CD)

Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

Marina Kreutz (M)

Leibniz Institute for Immunotherapy (LIT), 93053 Regensburg, Germany; Department of Internal Medicine III, University Hospital Regensburg, 93053 Regensburg, Germany.

Benedikt Brors (B)

Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

Ines Ugele (I)

Department of Otorhinolaryngology, University Hospital Regensburg, 93053 Regensburg, Germany.

Jens M Werner (JM)

Department of Surgery, University Hospital Regensburg, 93053 Regensburg, Germany.

Peter J Siska (PJ)

Department of Internal Medicine III, University Hospital Regensburg, 93053 Regensburg, Germany.

Christian Schmidl (C)

Leibniz Institute for Immunotherapy (LIT), 93053 Regensburg, Germany. Electronic address: christian.schmidl@ukr.de.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Integrated single-cell profiling dissects...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Integrated single-cell profiling dissects...
questionsmedicales.fr › Tumeurs › Integrated single-cell profiling dissects...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Séquences d'acides nucléiques régulatrices › Integrated single-cell profiling dissects...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Integrated single-cell profiling dissects...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Integrated single-cell profiling dissects...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes TIL › Integrated single-cell profiling dissects...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Éléments activateurs (génétique) › Integrated single-cell profiling dissects...