TLR 2/1 interaction of pectin depends on its chemical structure and conformation.

Humans Toll-Like Receptor 2 Molecular Docking Simulation Molecular Conformation Esters Pectins / chemistry
Citrus pectin HILIC-MS HPAEC Immunomodulation Methyl-ester distribution Toll-like receptors

Journal

Carbohydrate polymers
ISSN: 1879-1344
Titre abrégé: Carbohydr Polym
Pays: England
ID NLM: 8307156

Informations de publication

Date de publication:
01 Mar 2023
Historique:
received: 07 09 2022
revised: 18 11 2022
accepted: 05 12 2022
entrez: 19 1 2023
pubmed: 20 1 2023
medline: 24 1 2023
Statut: ppublish

Résumé

Citrus pectins have demonstrated health benefits through direct interaction with Toll-like receptor 2. Methyl-ester distribution patterns over the homogalacturonan were found to contribute to such immunomodulatory activity, therefore molecular interactions with TLR2 were studied. Molecular-docking analysis was performed using four GalA-heptamers, GalA

Identifiants

DOI: 10.1016/j.carbpol.2022.120444 PMID: 36657837
pubmed: 36657837
pii: S0144-8617(22)01349-2
doi: 10.1016/j.carbpol.2022.120444
pii:
doi:

Substances chimiques

Toll-Like Receptor 2 0
Esters 0
Pectins 89NA02M4RX

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

120444

Informations de copyright

Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Éva Jermendi (É)

Laboratory of Food Chemistry, Wageningen University, Bornse Weilanden 9, 6708, WG, Wageningen, the Netherlands. Electronic address: eva.jermendi@wur.nl.

Cynthia Fernández-Lainez (C)

Immunoendocrinology, Division of Medical Biology, Department of Pathology and Medical Biology, University Medical Center Groningen, Hanzeplein 1, 9713, GZ, Groningen, the Netherlands; Laboratorio de Errores Innatos del Metabolismo y Tamiz, Instituto Nacional de Pediatría, Av. Imán 1, piso 9, col. Insurgentes Cuicuilco 04530, Ciudad de México, Mexico. Electronic address: c.fernandez.lainez@umcg.nl.

Martin Beukema (M)

Immunoendocrinology, Division of Medical Biology, Department of Pathology and Medical Biology, University Medical Center Groningen, Hanzeplein 1, 9713, GZ, Groningen, the Netherlands. Electronic address: m.beukema@umcg.nl.

Gabriel López-Velázquez (G)

Laboratorio de Biomoléculas y Salud Infantil, Instituto Nacional de Pediatría, Av. Imán 1, piso 5, col. Insurgentes Cuicuilco 04530, Ciudad de México, Mexico. Electronic address: glv_1999@ciencias.unam.mx.

Marco A van den Berg (MA)

DSM Food & Beverages, Alexander Fleminglaan 1, 2613, AX, Delft, the Netherlands. Electronic address: marco.berg-van-den@dsm.com.

Paul de Vos (P)

Immunoendocrinology, Division of Medical Biology, Department of Pathology and Medical Biology, University Medical Center Groningen, Hanzeplein 1, 9713, GZ, Groningen, the Netherlands. Electronic address: p.de.vos@umcg.nl.

Henk A Schols (HA)

Laboratory of Food Chemistry, Wageningen University, Bornse Weilanden 9, 6708, WG, Wageningen, the Netherlands. Electronic address: henk.schols@wur.nl.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › TLR 2/1 interaction of pectin depends on its...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs de reconnaissance de motifs moléculaires › Récepteurs de type Toll › Récepteur de type Toll-2 › TLR 2/1 interaction of pectin depends on its...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › TLR 2/1 interaction of pectin depends on its...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › TLR 2/1 interaction of pectin depends on its...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Esters › TLR 2/1 interaction of pectin depends on its...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Préparations à base de plantes › Pectine › TLR 2/1 interaction of pectin depends on its...