Metabolic deuterium oxide (D
Deuterium oxide
Metabolic labeling
Omics
Relative quantification
Turnover rate
Journal
Analytica chimica acta
ISSN: 1873-4324
Titre abrégé: Anal Chim Acta
Pays: Netherlands
ID NLM: 0370534
Informations de publication
Date de publication:
15 Feb 2023
15 Feb 2023
Historique:
received:
29
08
2022
revised:
25
11
2022
accepted:
13
12
2022
entrez:
19
1
2023
pubmed:
20
1
2023
medline:
24
1
2023
Statut:
ppublish
Résumé
Mass spectrometry (MS) is an invaluable tool for sensitive detection and characterization of individual biomolecules in omics studies. MS combined with stable isotope labeling enables the accurate and precise determination of quantitative changes occurring in biological samples. Metabolic isotope labeling, wherein isotopes are introduced into biomolecules through biosynthetic metabolism, is one of the main labeling strategies. Among the precursors employed in metabolic isotope labeling, deuterium oxide (D
Identifiants
pubmed: 36657897
pii: S0003-2670(22)01293-4
doi: 10.1016/j.aca.2022.340722
pii:
doi:
Substances chimiques
Deuterium Oxide
J65BV539M3
Isotopes
0
Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
340722Informations de copyright
Copyright © 2022 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.