Avidity-based bright and photostable light-up aptamers for single-molecule mRNA imaging.


Journal

Nature chemical biology
ISSN: 1552-4469
Titre abrégé: Nat Chem Biol
Pays: United States
ID NLM: 101231976

Informations de publication

Date de publication:
04 2023
Historique:
received: 26 01 2022
accepted: 17 11 2022
medline: 31 3 2023
pubmed: 20 1 2023
entrez: 19 1 2023
Statut: ppublish

Résumé

Fluorescent light-up aptamers (FLAPs) have emerged as valuable tools to visualize RNAs, but are mostly limited by their poor brightness, low photostability, and high fluorescence background in live cells. Exploiting the avidity concept, here we present two of the brightest FLAPs with the strongest aptamer-dye interaction, high fluorogenicity, and remarkable photostability. They consist of dimeric fluorophore-binding aptamers (biRhoBAST and biSiRA) embedded in an RNA scaffold and their bivalent fluorophore ligands (bivalent tetramethylrhodamine TMR

Identifiants

pubmed: 36658339
doi: 10.1038/s41589-022-01228-8
pii: 10.1038/s41589-022-01228-8
doi:

Substances chimiques

RNA, Messenger 0
Aptamers, Nucleotide 0
RNA 63231-63-0
Fluorescent Dyes 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

478-487

Informations de copyright

© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.

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Auteurs

Bastian Bühler (B)

Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany.

Janin Schokolowski (J)

Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany.

Anja Benderoth (A)

Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany.

Daniel Englert (D)

Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany.

Franziska Grün (F)

Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany.

Andres Jäschke (A)

Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany. jaeschke@uni-hd.de.

Murat Sunbul (M)

Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany. msunbul@uni-heidelberg.de.

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