Involvement of Vasopressin in Tissue Hypoperfusion during Cardiogenic Shock Complicating Acute Myocardial Infarction in Rats.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
10 Jan 2023
Historique:
received: 21 12 2022
revised: 04 01 2023
accepted: 08 01 2023
entrez: 21 1 2023
pubmed: 22 1 2023
medline: 25 1 2023
Statut: epublish

Résumé

Acute heart failure (AHF) due to acute myocardial infarction (AMI) is likely to involve cardiogenic shock (CS), with neuro-hormonal activation. A relationship between AHF, CS and vasopressin response is suspected. This study aimed to investigate the implication of vasopressin on hemodynamic parameters and tissue perfusion at the early phase of CS complicating AMI. Experiments were performed on male Wistar rats submitted or not to left coronary artery ligation (AMI and Sham). Six groups were studied Sham and AMI treated or not with either a vasopressin antagonist SR-49059 (Sham-SR, AMI-SR) or agonist terlipressin (Sham-TLP, AMI-TLP). Animals were sacrificed one day after surgery (D

Identifiants

pubmed: 36674841
pii: ijms24021325
doi: 10.3390/ijms24021325
pmc: PMC9866678
pii:
doi:

Substances chimiques

Antidiuretic Hormone Receptor Antagonists 0
Vasopressins 11000-17-2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Philippe Gaudard (P)

PhyMedExp, Université Montpellier, INSERM, CNRS, 34295 Montpellier, France.

Hélène David (H)

CHU de Montpellier, 34090 Montpellier, France.

Patrice Bideaux (P)

PhyMedExp, Université Montpellier, INSERM, CNRS, 34295 Montpellier, France.

Pierre Sicard (P)

PhyMedExp, Université Montpellier, INSERM, CNRS, 34295 Montpellier, France.

Jean-Paul Cristol (JP)

CHU de Montpellier, 34090 Montpellier, France.

Gilles Guillon (G)

Institut de Génomique Fonctionnelle, Université Montpellier, INSERM, CNRS, 34094 Montpellier, France.

Sylvain Richard (S)

PhyMedExp, Université Montpellier, INSERM, CNRS, 34295 Montpellier, France.

Pascal Colson (P)

CHU de Montpellier, 34090 Montpellier, France.

Anne Virsolvy (A)

PhyMedExp, Université Montpellier, INSERM, CNRS, 34295 Montpellier, France.

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Classifications MeSH