Discovery and Biosynthesis of Glycosylated Cycloheximide from a Millipede-Associated Actinomycete.

Glycosylation Cycloheximide Actinobacteria / metabolism Glycosyltransferases / genetics Glycosides

Journal

Journal of natural products
ISSN: 1520-6025
Titre abrégé: J Nat Prod
Pays: United States
ID NLM: 7906882

Informations de publication

Date de publication:
24 02 2023
Historique:
pubmed: 25 1 2023
medline: 3 3 2023
entrez: 24 1 2023
Statut: ppublish

Résumé

Chemical redundancy of microbial natural products (NPs) underscores the importance to exploit new resources of microorganisms. Insect-associated microbes are prolific but largely underexplored sources of diverse NPs. Herein, we discovered the new compound

Identifiants

DOI: 10.1021/acs.jnatprod.2c00951 PMID: 36693198
pubmed: 36693198
doi: 10.1021/acs.jnatprod.2c00951
doi:

Substances chimiques

Cycloheximide 98600C0908
Glycosyltransferases EC 2.4.-
Glycosides 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

340-345

Auteurs

Jia-Qi Hu (JQ)

State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, 266237 Qingdao, People's Republic of China.

Ai Zhang (A)

Fetal Medicine Center, Qingdao Women and Children's Hospital, Qingdao University, 266071 Qingdao, People's Republic of China.

Han Wang (H)

State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, 266237 Qingdao, People's Republic of China.

Luo Niu (L)

State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, 266237 Qingdao, People's Republic of China.

Qing-Xia Wang (QX)

State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, 266237 Qingdao, People's Republic of China.

Le-Le Zhu (LL)

State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, 266237 Qingdao, People's Republic of China.

Yue-Zhong Li (YZ)

State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, 266237 Qingdao, People's Republic of China.
ORCID: 0000-0001-8336-6638

Changsheng Wu (C)

State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, 266237 Qingdao, People's Republic of China.
ORCID: 0000-0003-1310-0089

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Classifications MeSH

questionsmedicales.fr › Métabolisme › Métabolisme glucidique › Glycosylation › Discovery and Biosynthesis of Glycosylated...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipéridines › Pipéridones › Cycloheximide › Discovery and Biosynthesis of Glycosylated...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes irréguliers à Gram positif › Actinobacteria › Discovery and Biosynthesis of Glycosylated...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Discovery and Biosynthesis of Glycosylated...
questionsmedicales.fr › Glucides › Hétérosides › Discovery and Biosynthesis of Glycosylated...