Touch neurons underlying dopaminergic pleasurable touch and sexual receptivity.
peripheral optogenetics
pleasure
reward pathway
spinal cord
touch
Journal
Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066
Informations de publication
Date de publication:
02 02 2023
02 02 2023
Historique:
received:
05
11
2021
revised:
21
10
2022
accepted:
20
12
2022
pmc-release:
02
02
2024
pubmed:
25
1
2023
medline:
8
2
2023
entrez:
24
1
2023
Statut:
ppublish
Résumé
Pleasurable touch is paramount during social behavior, including sexual encounters. However, the identity and precise role of sensory neurons that transduce sexual touch remain unknown. A population of sensory neurons labeled by developmental expression of the G protein-coupled receptor Mrgprb4 detects mechanical stimulation in mice. Here, we study the social relevance of Mrgprb4-lineage neurons and reveal that these neurons are required for sexual receptivity and sufficient to induce dopamine release in the brain. Even in social isolation, optogenetic stimulation of Mrgprb4-lineage neurons through the back skin is sufficient to induce a conditioned place preference and a striking dorsiflexion resembling the lordotic copulatory posture. In the absence of Mrgprb4-lineage neurons, female mice no longer find male mounts rewarding: sexual receptivity is supplanted by aggression and a coincident decline in dopamine release in the nucleus accumbens. Together, these findings establish that Mrgprb4-lineage neurons initiate a skin-to-brain circuit encoding the rewarding quality of social touch.
Identifiants
pubmed: 36693373
pii: S0092-8674(22)01577-X
doi: 10.1016/j.cell.2022.12.034
pmc: PMC9898224
mid: NIHMS1860527
pii:
doi:
Substances chimiques
Dopamine
VTD58H1Z2X
MrgprB4 protein, mouse
0
Receptors, G-Protein-Coupled
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
577-590.e16Subventions
Organisme : NINDS NIH HHS
ID : DP2 NS130454
Pays : United States
Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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