Peroxide-cleavable linkers for antibody-drug conjugates.
Journal
Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838
Informations de publication
Date de publication:
09 Feb 2023
09 Feb 2023
Historique:
pubmed:
2
2
2023
medline:
11
2
2023
entrez:
1
2
2023
Statut:
epublish
Résumé
Antibody-drug conjugates containing peroxide-cleavable arylboronic acid linkers are described, which target the high levels of reactive oxygen species (ROS) in cancer. The arylboronic acid linkers rapidly release a payload in the presence of hydrogen peroxide, but remain stable in plasma. Anti-HER2 and PD-L1 peroxide-cleavable ADCs exhibited potent cytotoxicity
Identifiants
pubmed: 36722863
doi: 10.1039/d2cc06677g
pmc: PMC9910056
doi:
Substances chimiques
Immunoconjugates
0
Peroxides
0
Antineoplastic Agents
0
Hydrogen Peroxide
BBX060AN9V
Acids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1841-1844Références
Chem Soc Rev. 2019 Aug 12;48(16):4361-4374
pubmed: 31294429
Tetrahedron Lett. 2018 Oct 3;59(40):3594-3599
pubmed: 31156276
Mol Cancer Ther. 2016 May;15(5):958-70
pubmed: 26944918
Biochim Biophys Acta Mol Cell Res. 2019 Dec;1866(12):118526
pubmed: 31398408
Chem Sci. 2018 Nov 9;10(3):694-700
pubmed: 30774870
Chem Commun (Camb). 2022 Feb 8;58(12):1962-1965
pubmed: 35044383
Angew Chem Int Ed Engl. 2017 Mar 1;56(10):2619-2622
pubmed: 28120377
Nat Rev Drug Discov. 2017 May;16(5):315-337
pubmed: 28303026
Eur J Med Chem. 2017 Dec 15;142:393-415
pubmed: 28911823
Chem Soc Rev. 2022 Nov 14;51(22):9182-9202
pubmed: 36322071
Cancer Res. 2008 Nov 15;68(22):9280-90
pubmed: 19010901
J Med Chem. 2018 Apr 26;61(8):3503-3515
pubmed: 29605999
Cancers (Basel). 2020 Mar 21;12(3):
pubmed: 32245171
Medchemcomm. 2019 May 8;10(9):1531-1549
pubmed: 31673314
ChemMedChem. 2019 Aug 6;14(15):1384-1391
pubmed: 31207139
Nat Biotechnol. 2003 Jul;21(7):778-84
pubmed: 12778055
Bioorg Chem. 2019 Oct;91:103158
pubmed: 31376782
Cancers (Basel). 2019 Feb 16;11(2):
pubmed: 30781490
J Med Chem. 2012 Jan 26;55(2):924-34
pubmed: 22185340