Inflammasome activation by Gram-positive bacteria: Mechanisms of activation and regulation.
Gram-positive bacteria
autophagy
inflammasome
mechanisms of activation
regulation
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
21
10
2022
accepted:
06
01
2023
entrez:
10
2
2023
pubmed:
11
2
2023
medline:
14
2
2023
Statut:
epublish
Résumé
The inflammasomes are intracellular multimeric protein complexes consisting of an innate immune sensor, the adapter protein ASC and the inflammatory caspases-1 and/or -11 and are important for the host defense against pathogens. Activaton of the receptor leads to formation of the inflammasomes and subsequent processing and activation of caspase-1 that cleaves the proinflammatory cytokines IL-1β and IL-18. Active caspase-1, and in some instances caspase-11, cleaves gasdermin D that translocates to the cell membrane where it forms pores resulting in the cell death program called pyroptosis. Inflammasomes can detect a range of microbial ligands through direct interaction or indirectly through diverse cellular processes including changes in ion fluxes, production of reactive oxygen species and disruption of various host cell functions. In this review, we will focus on the NLRP3, NLRP6, NLRC4 and AIM2 inflammasomes and how they are activated and regulated during infections with Gram-positive bacteria, including
Identifiants
pubmed: 36761775
doi: 10.3389/fimmu.2023.1075834
pmc: PMC9902775
doi:
Substances chimiques
Inflammasomes
0
Carrier Proteins
0
Caspases
EC 3.4.22.-
Cytokines
0
Caspase 1
EC 3.4.22.36
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1075834Informations de copyright
Copyright © 2023 Keestra-Gounder and Nagao.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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