Phosphoproteomics Profiling Defines a Target Landscape of the Basophilic Protein Kinases AKT, S6K, and RSK in Skeletal Myotubes.

Muscle Fibers, Skeletal / metabolism Phosphatidylinositol 3-Kinases / metabolism Phosphorylation Proto-Oncogene Proteins c-akt / genetics Signal Transduction / physiology Ribosomal Protein S6 Kinases, 90-kDa Ribosomal Protein S6 Kinases, 70-kDa
RXRXXS/T motif cross talk kinase inhibitors kinase−substrate enrichment analysis (KSEA) kinase−substrate relationship label-free mass spectrometry parallel reaction monitoring (PRM) protein phosphorylation quantification signal transduction skeletal muscle cells stable isotope labeling by amino acids in cell culture text mining

Journal

Journal of proteome research
ISSN: 1535-3907
Titre abrégé: J Proteome Res
Pays: United States
ID NLM: 101128775

Informations de publication

Date de publication:
03 03 2023
Historique:
pubmed: 11 2 2023
medline: 7 3 2023
entrez: 10 2 2023
Statut: ppublish

Résumé

Phosphorylation-dependent signal transduction plays an important role in regulating the functions and fate of skeletal muscle cells. Central players in the phospho-signaling network are the protein kinases AKT, S6K, and RSK as part of the PI3K-AKT-mTOR-S6K and RAF-MEK-ERK-RSK pathways. However, despite their functional importance, knowledge about their specific targets is incomplete because these kinases share the same basophilic substrate motif RxRxx

Identifiants

DOI: 10.1021/acs.jproteome.2c00505 PMID: 36763541
pubmed: 36763541
doi: 10.1021/acs.jproteome.2c00505
doi:

Substances chimiques

Phosphatidylinositol 3-Kinases EC 2.7.1.-
Proto-Oncogene Proteins c-akt EC 2.7.11.1
Ribosomal Protein S6 Kinases, 90-kDa EC 2.7.11.1
Ribosomal Protein S6 Kinases, 70-kDa EC 2.7.11.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

768-789

Auteurs

Anna L Fricke (AL)

Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.
Biochemistry II, Theodor Boveri-Institute, Biocenter, University of Würzburg, 97074 Würzburg, Germany.

Wignand W D Mühlhäuser (WWD)

Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.

Lena Reimann (L)

Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.

Johannes P Zimmermann (JP)

Biochemistry II, Theodor Boveri-Institute, Biocenter, University of Würzburg, 97074 Würzburg, Germany.
ORCID: 0000-0001-5692-2096

Christa Reichenbach (C)

Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.

Bettina Knapp (B)

Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.

Christian D Peikert (CD)

Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.

Alexander M Heberle (AM)

Institute of Biochemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck, 6020 Innsbruck, Austria.
ORCID: 0000-0001-6414-8707

Erik Faessler (E)

Jena University Language & Information Engineering (JULIE) Lab, Friedrich Schiller University Jena, 07743 Jena, Germany.
ORCID: 0000-0003-1193-5103

Sascha Schäuble (S)

Jena University Language & Information Engineering (JULIE) Lab, Friedrich Schiller University Jena, 07743 Jena, Germany.
Systems Biology and Bioinformatics Unit, Leibniz Institute for Natural Product Research and Infection Biology─Leibniz-HKI, 07745 Jena, Germany.
ORCID: 0000-0003-3862-6546

Udo Hahn (U)

Jena University Language & Information Engineering (JULIE) Lab, Friedrich Schiller University Jena, 07743 Jena, Germany.

Kathrin Thedieck (K)

Institute of Biochemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck, 6020 Innsbruck, Austria.
Department of Pediatrics, Section Systems Medicine of Metabolism and Signaling, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, The Netherlands.
Department for Neuroscience, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg 26129, Germany.
ORCID: 0000-0002-9069-2930

Gerald Radziwill (G)

Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.
Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany.

Bettina Warscheid (B)

Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.
Biochemistry II, Theodor Boveri-Institute, Biocenter, University of Würzburg, 97074 Würzburg, Germany.
Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany.
ORCID: 0000-0001-5096-1975

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules musculaires › Fibres musculaires squelettiques › Phosphoproteomics Profiling Defines a Target...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphatidylinositol 3-kinases › Phosphoproteomics Profiling Defines a Target...
questionsmedicales.fr › Métabolisme › Phosphorylation › Phosphoproteomics Profiling Defines a Target...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-akt › Phosphoproteomics Profiling Defines a Target...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Phosphoproteomics Profiling Defines a Target...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Ribosomal Protein S6 Kinases › Ribosomal Protein S6 Kinases, 90-kDa › Phosphoproteomics Profiling Defines a Target...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Ribosomal Protein S6 Kinases › Ribosomal Protein S6 Kinases, 70-kDa › Phosphoproteomics Profiling Defines a Target...