Trained immunity and epigenetic memory in long-term self-renewing hematopoietic cells.

Immunity, Innate / genetics Trained Immunity Epigenetic Memory Macrophages Immunologic Memory / genetics

Journal

Experimental hematology
ISSN: 1873-2399
Titre abrégé: Exp Hematol
Pays: Netherlands
ID NLM: 0402313

Informations de publication

Date de publication:
05 2023
Historique:
received: 27 12 2022
revised: 31 01 2023
accepted: 01 02 2023
medline: 28 4 2023
pubmed: 11 2 2023
entrez: 10 2 2023
Statut: ppublish

Résumé

Immunologic memory is a feature typically ascribed to the adaptive arm of the immune system. However, recent studies have demonstrated that hematopoietic stem cells (HSCs) and innate immune cells such as monocytes and macrophages can gain epigenetic signatures to enhance their response in the context of reinfection. This suggests the presence of long-term memory, a phenomenon referred to as trained immunity. Trained immunity in HSCs can occur via changes in the epigenetic landscape and enhanced chromatin accessibility in lineage-specific genes, as well as through metabolic alterations. These changes can lead to a skewing in lineage bias, particularly enhanced myelopoiesis and the generation of epigenetically modified innate immune cells that provide better protection against pathogens on secondary infection. Here, we summarize recent advancements in trained immunity and epigenetic memory formation in HSCs and self-renewing alveolar macrophages, which was the focus of the Spring 2022 International Society for Experimental Hematology (ISEH) webinar.

Identifiants

DOI: 10.1016/j.exphem.2023.02.001 PMID: 36764598
pubmed: 36764598
pii: S0301-472X(23)00028-0
doi: 10.1016/j.exphem.2023.02.001
pii:
doi:

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6-11

Informations de copyright

Copyright © 2023 ISEH -- Society for Hematology and Stem Cells. All rights reserved.

Auteurs

Alban Johansson (A)

International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan.

Dawn S Lin (DS)

Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany. Electronic address: shuiping.lin@dkfz-heidelberg.de.

Francois E Mercier (FE)

Lady Davis Institute for Medical Research, Department of Medicine, McGill University, Montreal, Canada.

Masayuki Yamashita (M)

Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

Maziar Divangahi (M)

Department of Medicine, Department of Pathology, Department of Microbiology and Immunology, Research Institute McGill University Health Centre, McGill International TB Centre, Meakins-Christie Laboratories, McGill University, Montreal, Canada.

Michael H Sieweke (MH)

Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden, Dresden, Germany; Aix Marseille University, CNRS, INSERM, CIML, Marseille, France.

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Classifications MeSH

questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité innée › Trained immunity and epigenetic memory in...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité innée › Immunité entraînée › Trained immunity and epigenetic memory in...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Mémoire épigénétique › Trained immunity and epigenetic memory in...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Trained immunity and epigenetic memory in...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Mémoire immunologique › Trained immunity and epigenetic memory in...