Gut Microbiome Composition in Dystonia Patients.
dystonia
gut microbiome
gut–brain axis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
25 Jan 2023
25 Jan 2023
Historique:
received:
20
12
2022
revised:
17
01
2023
accepted:
21
01
2023
entrez:
11
2
2023
pubmed:
12
2
2023
medline:
15
2
2023
Statut:
epublish
Résumé
Dystonia is a movement disorder in which patients have involuntary abnormal movements or postures. Non-motor symptoms, such as psychiatric symptoms, sleep problems and fatigue, are common. We hypothesise that the gut microbiome might play a role in the pathophysiology of the (non-)motor symptoms in dystonia via the gut-brain axis. This exploratory study investigates the composition of the gut microbiome in dystonia patients compared to healthy controls. Furthermore, the abundance of neuro-active metabolic pathways, which might be implicated in the (non-)motor symptoms, was investigated. We performed both metagenomic and 16S rRNA sequencing on the stool samples of three subtypes of dystonia (27 cervical dystonia, 20 dopa-responsive dystonia and 24 myoclonus-dystonia patients) and 25 controls. While microbiome alpha and beta diversity was not different between dystonia patients and controls, dystonia patients had higher abundances of
Identifiants
pubmed: 36768705
pii: ijms24032383
doi: 10.3390/ijms24032383
pmc: PMC9916458
pii:
doi:
Substances chimiques
RNA, Ribosomal, 16S
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Biotechniques. 2004 May;36(5):808-12
pubmed: 15152600
Psychiatr Danub. 2018 Jun;30(2):136-141
pubmed: 29930222
Trends Microbiol. 2020 Jul;28(7):519-522
pubmed: 32544438
Cell Transplant. 2019 Dec;28(12):1507-1527
pubmed: 31512505
Physiol Rev. 2019 Oct 1;99(4):1877-2013
pubmed: 31460832
J Parkinsons Dis. 2017;7(2):331-346
pubmed: 28234259
Ann Neurol. 2021 Jun;89(6):1195-1211
pubmed: 33876477
Tremor Other Hyperkinet Mov (N Y). 2017 Oct 23;7:506
pubmed: 29123945
Cell Host Microbe. 2018 Jun 13;23(6):716-724
pubmed: 29902437
Nat Commun. 2018 Aug 17;9(1):3294
pubmed: 30120222
Clin Chem. 2019 Nov;65(11):1388-1396
pubmed: 31551315
Trends Neurosci. 2013 May;36(5):305-12
pubmed: 23384445
Parkinsonism Relat Disord. 2016 Nov;32:66-72
pubmed: 27591074
J Neuroinflammation. 2019 Mar 1;16(1):53
pubmed: 30823925
Int J Syst Evol Microbiol. 2002 Mar;52(Pt 2):423-428
pubmed: 11931151
J Clin Invest. 2015 Mar 2;125(3):926-38
pubmed: 25689247
Chronobiol Int. 2020 Jul;37(7):1067-1081
pubmed: 32602753
Nat Rev Microbiol. 2004 Feb;2(2):123-40
pubmed: 15040260
Parkinsonism Relat Disord. 2016 Sep;30:7-12
pubmed: 27321988
Microbiome. 2017 Feb 1;5(1):14
pubmed: 28143587
Neurosci Biobehav Rev. 2016 Jun;65:264-75
pubmed: 27073048
Neurogastroenterol Motil. 2012 May;24(5):405-13
pubmed: 22404222
Adv Neurol. 2002;89:361-76
pubmed: 11968461
Behav Brain Res. 2015 Jan 15;277:32-48
pubmed: 25078296
Parkinsonism Relat Disord. 2019 Dec;69:85-90
pubmed: 31706131
Anal Chem. 2020 Jul 7;92(13):9072-9078
pubmed: 32484659
Curr Neurol Neurosci Rep. 2017 Oct 17;17(12):94
pubmed: 29039142
Mov Disord. 2011 Jun;26(7):1206-17
pubmed: 21484874
Ann Rheum Dis. 2019 May;78(5):590-593
pubmed: 30760471
Psychiatry (Edgmont). 2007 Jul;4(7):28-37
pubmed: 20526405
J Parkinsons Dis. 2019;9(s2):S297-S312
pubmed: 31498131
Brain. 2012 Jun;135(Pt 6):1668-81
pubmed: 21933808
J Clin Med. 2020 Feb 01;9(2):
pubmed: 32024079
Brain Res. 2018 Aug 15;1693(Pt B):128-133
pubmed: 29903615
Neurology. 1985 Jan;35(1):73-7
pubmed: 3966004
Int J Mol Sci. 2019 Mar 25;20(6):
pubmed: 30934533
Nucleic Acids Res. 2016 Jan 4;44(D1):D457-62
pubmed: 26476454
Microb Genom. 2021 Oct;7(10):
pubmed: 34605764
Nature. 2022 Apr;604(7907):732-739
pubmed: 35418674
Parkinsonism Relat Disord. 2021 Oct;91:48-54
pubmed: 34482194
Environ Microbiol. 2017 Jan;19(1):29-41
pubmed: 27928878
Nat Microbiol. 2019 Apr;4(4):623-632
pubmed: 30718848
Cell. 2015 Apr 9;161(2):264-76
pubmed: 25860609
Nat Rev Dis Primers. 2018 Sep 20;4(1):25
pubmed: 30237473
Sci Transl Med. 2022 Aug 31;14(660):eabn7566
pubmed: 36044594
mSphere. 2021 Aug 25;6(4):e0028321
pubmed: 34346706
Parkinsonism Relat Disord. 2017 Dec;45:57-62
pubmed: 29066160
Prog Neurobiol. 2019 Nov;182:101678
pubmed: 31404592
Mol Neurodegener. 2021 Feb 8;16(1):6
pubmed: 33557896
Nature. 2016 Jul 21;535(7612):376-81
pubmed: 27409811
Proc Nutr Soc. 2021 Feb;80(1):37-49
pubmed: 32238208
Nat Rev Neurol. 2015 Nov;11(11):625-36
pubmed: 26503923