Microsampling and enantioselective liquid chromatography coupled to mass spectrometry for chiral bioanalysis of novel psychoactive substances.

Stereoisomerism Methanol Tandem Mass Spectrometry / methods Chromatography, Liquid / methods Chromatography, High Pressure Liquid / methods
Crown ether-based chiral stationary phase Novel psychoactive substances (NPSs) Stereochemical characterization Ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS) Volumetric absorptive microsampling (VAMS)

Journal

Talanta
ISSN: 1873-3573
Titre abrégé: Talanta
Pays: Netherlands
ID NLM: 2984816R

Informations de publication

Date de publication:
15 May 2023
Historique:
received: 23 11 2022
revised: 25 01 2023
accepted: 06 02 2023
pubmed: 12 2 2023
medline: 15 3 2023
entrez: 11 2 2023
Statut: ppublish

Résumé

In this paper, the development of efficient enantioselective HPLC methods for the analysis of five benzofuran-substituted phenethylamines, two substituted tryptamines, and three substituted cathinones is described. For the first time, reversed-phase (eluents made up with acidic water-methanol solutions) and polar-ionic (eluent made up with an acetonitrile-methanol solution incorporating both an acidic and a basic additive) conditions fully compatible with mass spectrometry (MS) detectors were applied with a chiral stationary phase (CSP) incorporating the (+)-(18-crown-6)-tetracarboxylic acid chiral selector. Enantioresolution was achieved for nine compounds with α and R

Identifiants

DOI: 10.1016/j.talanta.2023.124332 PMID: 36773512
pubmed: 36773512
pii: S0039-9140(23)00083-8
doi: 10.1016/j.talanta.2023.124332
pii:
doi:

Substances chimiques

Methanol Y4S76JWI15

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

124332

Informations de copyright

Copyright © 2023 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Michele Protti (M)

Department of Pharmacy and Biotechnology (FaBiT), Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.

Ina Varfaj (I)

Department of Pharmaceutical Sciences, University of Perugia, Via Fabretti 48, 06123 Perugia, Italy.

Andrea Carotti (A)

Department of Pharmaceutical Sciences, University of Perugia, Via Fabretti 48, 06123 Perugia, Italy.

Daniele Tedesco (D)

Institute for Organic Synthesis and Photoreactivity, National Research Council, Via P. Gobetti 101, 40129 Bologna, Italy.

Manuela Bartolini (M)

Department of Pharmacy and Biotechnology (FaBiT), Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.

Alessandro Favilli (A)

Department of Medicine and Surgery, University of Perugia, Piazzale Gambuli 1, 06132 Perugia, Italy.

Sandro Gerli (S)

Department of Medicine and Surgery, University of Perugia, Piazzale Gambuli 1, 06132 Perugia, Italy; Center for Perinatal and Reproductive Medicine, University of Perugia, Santa Maria della Misericordia University Hospital, 06132 Perugia, Italy.

Laura Mercolini (L)

Department of Pharmacy and Biotechnology (FaBiT), Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy. Electronic address: laura.mercolini@unibo.it.

Roccaldo Sardella (R)

Department of Pharmaceutical Sciences, University of Perugia, Via Fabretti 48, 06123 Perugia, Italy; Center for Perinatal and Reproductive Medicine, University of Perugia, Santa Maria della Misericordia University Hospital, 06132 Perugia, Italy. Electronic address: roccaldo.sardella@unipg.it.

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Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Phénomènes de chimie organique › Isomérie › Stéréoisomérie › Microsampling and enantioselective liquid...
questionsmedicales.fr › Composés chimiques organiques › Alcools › Méthanol › Microsampling and enantioselective liquid...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse en tandem › Microsampling and enantioselective liquid...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Microsampling and enantioselective liquid...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Chromatographie en phase liquide à haute performance › Microsampling and enantioselective liquid...