Thrombospondin-1, CD47, and SIRPα display cell-specific molecular signatures in human islets and pancreata.

Humans CD47 Antigen / genetics Macrophages / metabolism Neoplasms / metabolism Receptors, Cell Surface / metabolism Thrombospondins / metabolism Thrombospondin 1 / genetics
CD47 SIRPα islets thrombospondin-1 type 1 diabetes

Journal

American journal of physiology. Endocrinology and metabolism
ISSN: 1522-1555
Titre abrégé: Am J Physiol Endocrinol Metab
Pays: United States
ID NLM: 100901226

Informations de publication

Date de publication:
01 04 2023
Historique:
medline: 30 3 2023
pubmed: 16 2 2023
entrez: 15 2 2023
Statut: ppublish

Résumé

Thrombospondin-1 (TSP1) is a secreted protein minimally expressed in health but increased in disease and age. TSP1 binds to the cell membrane receptor CD47, which itself engages signal regulatory protein α (SIRPα), and the latter creates a checkpoint for immune activation. Individuals with cancer administered checkpoint-blocking molecules developed insulin-dependent diabetes. Relevant to this, CD47 blocking antibodies and SIRPα fusion proteins are in clinical trials. We characterized the molecular signature of TSP1, CD47, and SIRPα in human islets and pancreata. Fresh islets and pancreatic tissue from nondiabetic individuals were obtained. The expression of

Identifiants

DOI: 10.1152/ajpendo.00221.2022 PMID: 36791324
pubmed: 36791324
doi: 10.1152/ajpendo.00221.2022
doi:

Substances chimiques

CD47 Antigen 0
Receptors, Cell Surface 0
Thrombospondins 0
Thrombospondin 1 0
CD47 protein, human 0

Banques de données

figshare
['10.6084/m9.figshare.22006958.v1', '10.6084/m9.figshare.22006943.v1', '10.6084/m9.figshare.21861684.v1', '10.6084/m9.figshare.21861678.v1']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

E347-E357

Subventions

Organisme : NIDDK NIH HHS
ID : U24 DK098085
Pays : United States

Auteurs

Neslihan Erdem (N)

Irell & Manella Graduate School of Biological Sciences, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States.
Department of Molecular & Cellular Endocrinology, City of Hope National Medical Center, Duarte, California, United States.
Department of Translational Research & Cellular Therapeutics, City of Hope National Medical Center, Duarte, California, United States.
Arthur Riggs Diabetes & Metabolism Research Institute, City of Hope National Medical Center, Duarte, California, United States.
ORCID: 0000-0002-5554-1731

Kuan-Tsen Chen (KT)

Department of Translational Research & Cellular Therapeutics, City of Hope National Medical Center, Duarte, California, United States.
Arthur Riggs Diabetes & Metabolism Research Institute, City of Hope National Medical Center, Duarte, California, United States.

Meirigeng Qi (M)

Department of Translational Research & Cellular Therapeutics, City of Hope National Medical Center, Duarte, California, United States.
Arthur Riggs Diabetes & Metabolism Research Institute, City of Hope National Medical Center, Duarte, California, United States.

Yuqi Zhao (Y)

Integrative Genomics Core, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States.

Xiwei Wu (X)

Integrative Genomics Core, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States.

Isaac Garcia (I)

Department of Molecular & Cellular Endocrinology, City of Hope National Medical Center, Duarte, California, United States.
Arthur Riggs Diabetes & Metabolism Research Institute, City of Hope National Medical Center, Duarte, California, United States.

Hsun Teresa Ku (HT)

Irell & Manella Graduate School of Biological Sciences, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States.
Department of Translational Research & Cellular Therapeutics, City of Hope National Medical Center, Duarte, California, United States.
Arthur Riggs Diabetes & Metabolism Research Institute, City of Hope National Medical Center, Duarte, California, United States.

Enrique Montero (E)

Arthur Riggs Diabetes & Metabolism Research Institute, City of Hope National Medical Center, Duarte, California, United States.

Ismail H Al-Abdullah (IH)

Department of Translational Research & Cellular Therapeutics, City of Hope National Medical Center, Duarte, California, United States.
Arthur Riggs Diabetes & Metabolism Research Institute, City of Hope National Medical Center, Duarte, California, United States.

Fouad Kandeel (F)

Department of Translational Research & Cellular Therapeutics, City of Hope National Medical Center, Duarte, California, United States.
Arthur Riggs Diabetes & Metabolism Research Institute, City of Hope National Medical Center, Duarte, California, United States.

Bart O Roep (BO)

Arthur Riggs Diabetes & Metabolism Research Institute, City of Hope National Medical Center, Duarte, California, United States.

Jeffrey S Isenberg (JS)

Department of Diabetes Complications & Metabolism, City of Hope National Medical Center, Duarte, California, United States.
Arthur Riggs Diabetes & Metabolism Research Institute, City of Hope National Medical Center, Duarte, California, United States.
ORCID: 0000-0002-4221-1688

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Thrombospondin-1, CD47, and SIRPα display...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Glycoprotéines membranaires › Antigènes CD47 › Thrombospondin-1, CD47, and SIRPα display...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Thrombospondin-1, CD47, and SIRPα display...
questionsmedicales.fr › Tumeurs › Thrombospondin-1, CD47, and SIRPα display...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Thrombospondin-1, CD47, and SIRPα display...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Glycoprotéines membranaires › Thrombospondines › Thrombospondin-1, CD47, and SIRPα display...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Glycoprotéines membranaires › Thrombospondines › Thrombospondine-1 › Thrombospondin-1, CD47, and SIRPα display...