Congenital hypothyroidism in children with eutopic gland or thyroid hemiagenesis: prognostic factors for transient vs. permanent hypothyroidism.
congenital hypothyroidism
drug therapy
neonatal screening
prognosis
thyroxine
Journal
Journal of pediatric endocrinology & metabolism : JPEM
ISSN: 2191-0251
Titre abrégé: J Pediatr Endocrinol Metab
Pays: Germany
ID NLM: 9508900
Informations de publication
Date de publication:
25 Apr 2023
25 Apr 2023
Historique:
received:
23
02
2022
accepted:
29
01
2023
medline:
6
4
2023
pubmed:
18
2
2023
entrez:
17
2
2023
Statut:
epublish
Résumé
More than one third of children with congenital hypothyroidism (CH) and thyroid gland We retrospectively reviewed medical records of 111 children, born between 1996 and 2017, diagnosed with congenital hypothyroidism and eutopic gland or hemiagenesis and treated at the Nancy Regional and University Hospital. Fifty four infants (48.6%) had permanent congenital hypothyroidism (PCH) and 57 (51.4%) transient congenital hypothyroidism (TCH). Prognostic factors for TCH included prematurity, twin pregnancy, low birth weight and Apgar score <7, while low FT3 at diagnosis, maternal levothyroxine treatment, a family history of thyroid dysfunction and TSH ≥10 mUI/L while receiving treatment were associated with PCH. Knee epiphyses on X-ray at diagnosis were absent only in children with PCH. The median levothyroxine dose during follow-up was significantly lower in the TCH group compared to the PCH group. A levothyroxine dose of ≤3.95, ≤2.56, ≤2.19 and ≤2.12 μg/kg/day at 6 months, 1, 2 and 3 years of follow-up, respectively, had the best sensitivity-to-specificity ratio for predicting TCH. Even though it remains difficult to predict the course of hypothyroidism at diagnosis, we were able to identify several prognostic factors for TCH including perinatal problems and lower levothyroxine requirements that can guide the physician on the evolution of hypothyroidism. Clinical Trial Registration Number: NCT04712760.
Identifiants
pubmed: 36798001
pii: jpem-2022-0101
doi: 10.1515/jpem-2022-0101
doi:
Substances chimiques
Thyroxine
Q51BO43MG4
Thyrotropin
9002-71-5
Banques de données
ClinicalTrials.gov
['NCT04712760']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
353-363Informations de copyright
© 2023 Walter de Gruyter GmbH, Berlin/Boston.
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