IL-21R signal reprogramming cooperates with CD40 and BCR signals to select and differentiate germinal center B cells.


Journal

Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624

Informations de publication

Date de publication:
24 02 2023
Historique:
pmc-release: 24 02 2024
entrez: 17 2 2023
pubmed: 18 2 2023
medline: 22 2 2023
Statut: ppublish

Résumé

Both B cell receptor (BCR) and CD40 signaling are rewired in germinal center (GC) B cells (GCBCs) to synergistically induce c-MYC and phosphorylated S6 ribosomal protein (p-S6), markers of positive selection. How interleukin-21 (IL-21), a key T follicular helper (T

Identifiants

pubmed: 36800413
doi: 10.1126/sciimmunol.add1823
pmc: PMC10206726
mid: NIHMS1887587
doi:

Substances chimiques

CD40 Antigens 0
Receptors, Antigen, B-Cell 0
Receptors, Interleukin-21 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadd1823

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI043603
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI105018
Pays : United States

Références

Nat Commun. 2021 Dec 9;12(1):7160
pubmed: 34887406
J Exp Med. 2013 Nov 18;210(12):2739-53
pubmed: 24218138
Front Immunol. 2019 Jan 09;9:3106
pubmed: 30687317
J Immunol. 2004 Nov 1;173(9):5361-71
pubmed: 15494482
Cell. 2020 Nov 25;183(5):1298-1311.e11
pubmed: 33125897
EMBO J. 1997 Jun 2;16(11):2996-3006
pubmed: 9214617
J Exp Med. 2021 Jan 4;218(1):
pubmed: 33045065
Immunity. 2003 Oct;19(4):607-20
pubmed: 14563324
Blood. 2014 Feb 13;123(7):1012-20
pubmed: 24277074
Proc Natl Acad Sci U S A. 2021 Jan 12;118(2):
pubmed: 33419925
Immunity. 2013 Nov 14;39(5):846-57
pubmed: 24120362
J Exp Med. 2006 Oct 30;203(11):2419-24
pubmed: 17030950
Nat Immunol. 2016 Oct;17(10):1216-1225
pubmed: 27500631
Blood. 2013 Dec 5;122(24):3940-50
pubmed: 24159173
Immunity. 2017 Dec 19;47(6):1142-1153.e4
pubmed: 29262350
J Exp Med. 2010 Feb 15;207(2):365-78
pubmed: 20142430
J Immunol. 2010 May 1;184(9):4615-9
pubmed: 20368279
Bioinformatics. 2014 Apr 1;30(7):923-30
pubmed: 24227677
J Exp Med. 2002 May 6;195(9):1215-21
pubmed: 11994427
Immunity. 1997 Mar;6(3):225-33
pubmed: 9075923
Immunol Rev. 2019 Mar;288(1):49-63
pubmed: 30874353
Immunity. 2017 Jun 20;46(6):1045-1058.e6
pubmed: 28636954
Oncogene. 2000 May 15;19(21):2628-37
pubmed: 10851062
EMBO Rep. 2022 Sep 5;23(9):e54677
pubmed: 35801309
J Exp Med. 2000 Oct 2;192(7):931-42
pubmed: 11015435
Gigascience. 2018 Jul 1;7(7):
pubmed: 30010766
Bioinformatics. 2010 Oct 1;26(19):2438-44
pubmed: 20709693
Sci STKE. 2003 May 27;2003(184):pe21
pubmed: 12771436
J Immunol. 2009 Dec 1;183(11):7314-25
pubmed: 19917681
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
Immunity. 2013 Jul 25;39(1):136-47
pubmed: 23850379
Immunity. 2007 May;26(5):555-66
pubmed: 17509907
Immunol Rev. 2012 May;247(1):52-63
pubmed: 22500831
Nature. 2015 Jan 8;517(7533):214-8
pubmed: 25317561
Nat Immunol. 2020 Mar;21(3):331-342
pubmed: 32066950
Immunity. 2022 Aug 9;55(8):1414-1430.e5
pubmed: 35896116
J Immunol. 2018 Dec 15;201(12):3569-3579
pubmed: 30446568
Science. 2007 Jan 26;315(5811):528-31
pubmed: 17185562
Nat Immunol. 2012 Nov;13(11):1092-100
pubmed: 23001146
Nat Immunol. 2016 Jul;17(7):861-9
pubmed: 27158841
J Exp Med. 2017 Nov 6;214(11):3435-3448
pubmed: 28939548
Nat Commun. 2011 Sep 06;2:465
pubmed: 21897376
Immunity. 2019 Aug 20;51(2):324-336.e5
pubmed: 31350178
J Exp Med. 2008 Dec 22;205(13):3019-29
pubmed: 19047437
Immunity. 2016 Sep 20;45(3):471-482
pubmed: 27653600
Immunity. 2018 Sep 18;49(3):477-489.e7
pubmed: 30231983
Genome Biol. 2014 Feb 03;15(2):R29
pubmed: 24485249
J Exp Med. 2010 Feb 15;207(2):353-63
pubmed: 20142429
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
J Exp Med. 2017 Mar 6;214(3):639-649
pubmed: 28143955
Immunity. 2018 Apr 17;48(4):702-715.e4
pubmed: 29669250
J Immunol. 2011 Nov 1;187(9):4553-60
pubmed: 21984700
Immunity. 2006 Aug;25(2):225-36
pubmed: 16919487
Science. 2017 Oct 13;358(6360):
pubmed: 28935768
Sci Immunol. 2023 Feb 24;8(80):eadd1728
pubmed: 36800411
Science. 2012 Jun 1;336(6085):1178-81
pubmed: 22555432
Curr Opin Immunol. 2020 Apr;63:29-34
pubmed: 31835060
J Exp Med. 2018 Apr 2;215(4):1227-1243
pubmed: 29549115
Nat Immunol. 2019 Jun;20(6):736-746
pubmed: 31011187
Immunity. 2016 Jan 19;44(1):116-130
pubmed: 26795247
J Exp Med. 2017 May 1;214(5):1259-1267
pubmed: 28363897
Immunity. 2018 Feb 20;48(2):313-326.e5
pubmed: 29396161
Nat Immunol. 2020 Sep;21(9):1082-1093
pubmed: 32601467
Nat Immunol. 2012 Nov;13(11):1083-91
pubmed: 23001145
Immunol Rev. 2019 Mar;288(1):64-74
pubmed: 30874351
Cell. 2010 Nov 12;143(4):592-605
pubmed: 21074050
J Immunol. 1999 Jul 15;163(2):611-7
pubmed: 10395648
Nature. 2021 Apr;592(7852):133-137
pubmed: 33597749

Auteurs

Wei Luo (W)

Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

Laura Conter (L)

Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

Rebecca A Elsner (RA)

Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

Shuchi Smita (S)

Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

Florian Weisel (F)

Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

Derrick Callahan (D)

Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

Shuxian Wu (S)

Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

Maria Chikina (M)

Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

Mark Shlomchik (M)

Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

Articles similaires

The FGF/FGFR/c-Myc axis as a promising therapeutic target in multiple myeloma.

Arianna Giacomini, Sara Taranto, Giorgia Gazzaroli et al.
1.00
Humans Multiple Myeloma Receptors, Fibroblast Growth Factor Fibroblast Growth Factors Proto-Oncogene Proteins c-myc
Animals Lung India Sheep Transcriptome

Calcineurin inhibition enhances

Priyanka Das, Alejandro Aballay, Jogender Singh
1.00
Animals Caenorhabditis elegans Longevity Caenorhabditis elegans Proteins Calcineurin
1.00
Animals Mice Immunity, Innate Interneurons Synapses

Classifications MeSH