Central amygdala angiotensin type 1 receptor (Agtr1) expressing neurons contribute to fear extinction.

Mice Animals Fear / physiology Central Amygdaloid Nucleus / metabolism Receptor, Angiotensin, Type 1 / genetics Extinction, Psychological Mice, Transgenic Neurons / metabolism
AT(1)R Amygdala Angiotensin II PTSD Pavlovian fear conditioning

Journal

Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217

Informations de publication

Date de publication:
15 05 2023
Historique:
received: 10 06 2022
revised: 12 01 2023
accepted: 08 02 2023
pubmed: 22 2 2023
medline: 21 3 2023
entrez: 21 2 2023
Statut: ppublish

Résumé

The renin-angiotensin system (RAS) has been linked to the pathophysiology of posttraumatic stress disorder (PTSD) however, the underlying neurobiological mechanism(s) remain elusive. Here we utilized angiotensin II receptor type 1 (AT

Identifiants

DOI: 10.1016/j.neuropharm.2023.109460 PMID: 36801399
pubmed: 36801399
pii: S0028-3908(23)00050-3
doi: 10.1016/j.neuropharm.2023.109460
pii:
doi:

Substances chimiques

Receptor, Angiotensin, Type 1 0

Types de publication

Journal Article Review Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

109460

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL137103
Pays : United States

Informations de copyright

Copyright © 2023. Published by Elsevier Ltd.

Auteurs

Zhe Yu (Z)

Department of Pharmacology and Physiology, George Washington University, Washington, DC, USA.

Alexandre Kisner (A)

Department of Pharmacology and Physiology, George Washington University, Washington, DC, USA.

Amy Bhatt (A)

Department of Pharmacology and Physiology, George Washington University, Washington, DC, USA.

Abigail M Polter (AM)

Department of Pharmacology and Physiology, George Washington University, Washington, DC, USA.

Paul J Marvar (PJ)

Department of Pharmacology and Physiology, George Washington University, Washington, DC, USA; Department of Psychiatry and Behavioral Sciences, George Washington University, School of Medicine and Health Sciences, Washington, DC, USA. Electronic address: pmarvar@gwu.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Central amygdala angiotensin type 1 receptor...
questionsmedicales.fr › Eucaryotes › Animaux › Central amygdala angiotensin type 1 receptor...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Peur › Central amygdala angiotensin type 1 receptor...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Amygdale (système limbique) › Noyau central de l'amygdale › Central amygdala angiotensin type 1 receptor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteurs aux angiotensines › Récepteur de type 1 à l'angiotensine-II › Central amygdala angiotensin type 1 receptor...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Renforcement (psychologie) › Extinction (psychologie) › Central amygdala angiotensin type 1 receptor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Central amygdala angiotensin type 1 receptor...
questionsmedicales.fr › Cellules › Neurones › Central amygdala angiotensin type 1 receptor...