Non-random Codon Usage of Synonymous and Non-synonymous Mutations in the Human HLA-A Gene.
Ancestral codons
Different deamination frequencies
Human HLA-A gene
Non-random sSNP3 mutations
Non-synonymous mutations (NSM)
Variable polymorphic areas
Journal
Journal of molecular evolution
ISSN: 1432-1432
Titre abrégé: J Mol Evol
Pays: Germany
ID NLM: 0360051
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
received:
29
04
2022
accepted:
13
01
2023
medline:
11
4
2023
pubmed:
23
2
2023
entrez:
22
2
2023
Statut:
ppublish
Résumé
The structure and function of human leucocyte antigen (HLA-A) is well known and is an extremely variable protein. From the public HLA-A database, we chose 26 high frequency HLA-A alleles (45% of sequenced alleles). Using five arbitrary references from these alleles, we analyzed synonymous mutations at the third codon position (sSNP
Identifiants
pubmed: 36809491
doi: 10.1007/s00239-023-10093-5
pii: 10.1007/s00239-023-10093-5
doi:
Substances chimiques
Codon
0
Cytosine
8J337D1HZY
HLA-A Antigens
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
169-191Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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