Involvement of GABAergic Interneuron Subtypes in 4-Aminopyridine-Induced Seizure-Like Events in Mouse Entorhinal Cortex

Animals Male Mice 4-Aminopyridine / toxicity Action Potentials / physiology Entorhinal Cortex Epilepsy, Temporal Lobe Interneurons / physiology Mice, Inbred C57BL Seizures / chemically induced
epilepsy in vitro slices interneurons patch clamp seizures

Journal

The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140

Informations de publication

Date de publication:
15 03 2023
Historique:
received: 17 06 2022
revised: 30 12 2022
accepted: 05 01 2023
pubmed: 23 2 2023
medline: 21 3 2023
entrez: 22 2 2023
Statut: ppublish

Résumé

Single-unit recordings performed in temporal lobe epilepsy patients and in models of temporal lobe seizures have shown that interneurons are active at focal seizure onset. We performed simultaneous patch-clamp and field potential recordings in entorhinal cortex slices of GAD65 and GAD67 C57BL/6J male mice that express green fluorescent protein in GABAergic neurons to analyze the activity of specific interneuron (IN) subpopulations during acute seizure-like events (SLEs) induced by 4-aminopyridine (4-AP; 100 μm). IN subtypes were identified as parvalbuminergic (IN

Identifiants

DOI: 10.1523/JNEUROSCI.1190-22.2023 PMID: 36810229 PMC: PMC10027059
pubmed: 36810229
pii: JNEUROSCI.1190-22.2023
doi: 10.1523/JNEUROSCI.1190-22.2023
pmc: PMC10027059
doi:

Substances chimiques

4-Aminopyridine BH3B64OKL9

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1987-2001

Subventions

Organisme : CIHR
ID : PJT153310
Pays : Canada
Organisme : CIHR
ID : PJT166178
Pays : Canada

Informations de copyright

Copyright © 2023 the authors.

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Auteurs

Paolo Scalmani (P)

Epilepsy Unit paolo.scalmani@istituto-besta.it.
ORCID: 0000-0002-3992-0926

Rosina Paterra (R)

Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano 20133, Italy.

Massimo Mantegazza (M)

Université Côte d'Azur, 06560 Valbonne-Sophia Antipolis, France.
Institute of Molecular and Cellular Pharmacology, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7275, Laboratoire d'Excellence/Canaux Ioniques d'Intérêt Thérapeutique, 06650 Valbonne-Sophia Antipolis, France.
Institut National de la Santé et de la Recherche Médicale, 06650 Valbonne-Sophia Antipolis, France.
ORCID: 0000-0002-1070-7929

Massimo Avoli (M)

Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada.
Departments of Neurology and Neurosurgery and Physiology, McGill University, Montreal, Quebec H3A 2B4, Canada.

Marco de Curtis (M)

Epilepsy Unit.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Involvement of GABAergic Interneuron Subtypes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Involvement of GABAergic Interneuron Subtypes...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Aminopyridines › 4-Amino-pyridine › Involvement of GABAergic Interneuron Subtypes...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Potentiels de membrane › Potentiels d'action › Involvement of GABAergic Interneuron Subtypes...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex olfactif › Cortex entorhinal › Involvement of GABAergic Interneuron Subtypes...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Épilepsie › Syndromes épileptiques › Épilepsie temporale › Involvement of GABAergic Interneuron Subtypes...
questionsmedicales.fr › Cellules › Neurones › Interneurones › Involvement of GABAergic Interneuron Subtypes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Involvement of GABAergic Interneuron Subtypes...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Crises épileptiques › Involvement of GABAergic Interneuron Subtypes...