Effects of exogenous oxytocin and estradiol on resting-state functional connectivity in women and men.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
22 02 2023
22 02 2023
Historique:
received:
15
11
2022
accepted:
09
02
2023
entrez:
22
2
2023
pubmed:
23
2
2023
medline:
25
2
2023
Statut:
epublish
Résumé
Possible interactions of the neuropeptide oxytocin and the sex hormone estradiol may contribute to previously observed sex-specific effects of oxytocin on resting-state functional connectivity (rsFC) of the amygdala and hippocampus. Therefore, we used a placebo-controlled, randomized, parallel-group functional magnetic resonance imaging study design and measured amygdala and hippocampus rsFC in healthy men (n = 116) and free-cycling women (n = 111), who received estradiol gel (2 mg) or placebo before the intranasal administration of oxytocin (24 IU) or placebo. Our results reveal significant interaction effects of sex and treatments on rsFC of the amygdala and hippocampus in a seed-to-voxel analysis. In men, both oxytocin and estradiol significantly decreased rsFC between the left amygdala and the right and left lingual gyrus, the right calcarine fissure, and the right superior parietal gyrus compared to placebo, while the combined treatment produced a significant increase in rsFC. In women, the single treatments significantly increased the rsFC between the right hippocampus and the left anterior cingulate gyrus, whereas the combined treatment had the opposite effect. Collectively, our study indicates that exogenous oxytocin and estradiol have different region-specific effects on rsFC in women and men and that the combined treatment may produce antagonistic effects.
Identifiants
pubmed: 36813823
doi: 10.1038/s41598-023-29754-y
pii: 10.1038/s41598-023-29754-y
pmc: PMC9947123
doi:
Substances chimiques
Oxytocin
50-56-6
Estradiol
4TI98Z838E
Types de publication
Randomized Controlled Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3113Informations de copyright
© 2023. The Author(s).
Références
Neuroimage. 2021 Feb 15;227:117668
pubmed: 33359350
Sci Rep. 2018 Oct 30;8(1):16042
pubmed: 30375425
Neuroscience. 2008 Apr 9;152(4):888-902
pubmed: 18353559
Psychol Sci. 2017 Dec;28(12):1763-1772
pubmed: 28968183
Neuroimage. 2022 Dec 1;264:119689
pubmed: 36349596
Psychoneuroendocrinology. 2021 Jun;128:105224
pubmed: 33878602
Front Neurosci. 2020 Feb 14;14:11
pubmed: 32116489
Neurosci Biobehav Rev. 2018 Dec;95:17-32
pubmed: 30243577
J Neurosci Res. 2017 Jan 2;95(1-2):576-586
pubmed: 27870395
Horm Behav. 2015 Aug;74:37-52
pubmed: 26122299
Front Neurosci. 2015 Feb 20;9:37
pubmed: 25750611
J Clin Psychiatry. 1998;59 Suppl 20:22-33;quiz 34-57
pubmed: 9881538
Cereb Cortex. 2020 Mar 21;30(2):824-835
pubmed: 31251328
Int J Neuropsychopharmacol. 2014 Oct 31;18(5):
pubmed: 25522395
Psychoneuroendocrinology. 2008 Nov;33(10):1419-25
pubmed: 18977091
Neuropsychopharmacology. 2022 Apr;47(5):1046-1054
pubmed: 34887528
Horm Behav. 2013 Feb;63(2):231-7
pubmed: 22587940
Sci Rep. 2019 Sep 26;9(1):13418
pubmed: 31558733
Hum Brain Mapp. 2013 May;34(5):1187-93
pubmed: 22162177
Neuropsychopharmacology. 2018 Feb;43(3):555-563
pubmed: 28741624
Hum Brain Mapp. 2014 Dec;35(12):6067-76
pubmed: 25094043
Physiol Behav. 1996 Nov;60(5):1209-15
pubmed: 8916173
Mol Psychiatry. 2018 Jan;23(1):115-122
pubmed: 28289281
Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20308-13
pubmed: 24277856
Nat Commun. 2020 Jun 3;11(1):2783
pubmed: 32494001
Asian J Androl. 2016 May-Jun;18(3):435-40
pubmed: 26908066
Nat Rev Neurol. 2021 Oct;17(10):621-633
pubmed: 34545218
Anat Embryol (Berl). 2005 Dec;210(5-6):343-52
pubmed: 16208455
Front Neuroendocrinol. 2019 Oct;55:100796
pubmed: 31580837
Physiol Rev. 2001 Apr;81(2):629-83
pubmed: 11274341
Sci Rep. 2013 Dec 06;3:3440
pubmed: 24310737
Neuroimage. 2012 Feb 15;59(4):3548-62
pubmed: 22116037
Hum Brain Mapp. 2019 Jan;40(1):242-251
pubmed: 30152573
J Neurosci. 2012 Nov 14;32(46):16074-9
pubmed: 23152592
Front Neuroendocrinol. 2022 Oct;67:101036
pubmed: 36126748
Sci Rep. 2018 Sep 21;8(1):14437
pubmed: 30237458
Biol Psychiatry. 2015 Aug 1;78(3):194-202
pubmed: 25542304
Biol Psychiatry. 2007 Nov 15;62(10):1187-90
pubmed: 17617382
J Neurosci. 2005 Dec 7;25(49):11489-93
pubmed: 16339042
Brain Connect. 2017 Sep;7(7):454-463
pubmed: 28762756
Am J Psychiatry. 2013 Oct;170(10):1169-77
pubmed: 23982273
Int J Neuropsychopharmacol. 2013 Mar;16(2):255-60
pubmed: 22647521
Neuropsychopharmacology. 2016 Mar;41(4):932-9
pubmed: 26272050
Sci Rep. 2020 Feb 11;10(1):2352
pubmed: 32047245
Cereb Cortex. 2021 Feb 5;31(3):1848-1860
pubmed: 30535355
Endocrinology. 1991 Feb;128(2):891-6
pubmed: 1846593
Front Endocrinol (Lausanne). 2015 Oct 15;6:160
pubmed: 26528239
Hum Brain Mapp. 2017 Sep;38(9):4525-4534
pubmed: 28580708
Soc Cogn Affect Neurosci. 2016 May;11(5):767-74
pubmed: 26722017
Psychoneuroendocrinology. 2018 May;91:206-215
pubmed: 29601981
Transl Psychiatry. 2017 Apr 18;7(4):e1099
pubmed: 28418398
Neuropsychopharmacology. 2015 Oct;40(11):2632-8
pubmed: 25881796
Dev Neurobiol. 2007 Sep 1;67(10):1321-33
pubmed: 17638384
Soc Cogn Affect Neurosci. 2013 Dec;8(8):897-902
pubmed: 22842905
Brain Connect. 2012;2(3):125-41
pubmed: 22642651
Neuroreport. 1998 Mar 30;9(5):933-6
pubmed: 9579693
Neuropsychopharmacology. 2021 Dec;46(13):2278-2287
pubmed: 34493827
Prog Neurobiol. 2018 Dec;171:1-14
pubmed: 30359747
Neuropsychopharmacology. 2015 Nov;40(12):2736-44
pubmed: 25924202
Neuropsychopharmacology. 2017 Jan;42(2):446-453
pubmed: 27649641
Magn Reson Med. 2011 Sep;66(3):644-57
pubmed: 21394769
Proc Natl Acad Sci U S A. 2010 May 18;107(20):9400-5
pubmed: 20421469
Psychoneuroendocrinology. 2016 Jul;69:50-9
pubmed: 27032063
Nat Med. 2017 Jan;23(1):28-38
pubmed: 27918562
Hippocampus. 2008;18(10):985-8
pubmed: 18767068
Neuropsychopharmacology. 2020 Jun;45(7):1134-1140
pubmed: 31785587
Psychoneuroendocrinology. 2018 Jun;92:95-102
pubmed: 29674171
Soc Cogn Affect Neurosci. 2013 Mar;8(3):313-7
pubmed: 22446301
Front Comput Neurosci. 2013 Apr 25;7:38
pubmed: 23630491
Neuroimage. 2014 Apr 15;90:24-32
pubmed: 24365676
Neuroimage. 2017 Apr 1;149:458-467
pubmed: 28161309
N Engl J Med. 2004 Oct 7;351(15):1548-63
pubmed: 15470219
Sci Rep. 2016 Nov 15;6:35054
pubmed: 27845765
Brain Behav Immun. 2023 Jan;107:90-97
pubmed: 36058418
Brain Struct Funct. 2020 Mar;225(2):591-605
pubmed: 31894405
Front Neurosci. 2015 Feb 23;9:44
pubmed: 25755630
Neuropsychopharmacology. 2019 Jan;44(2):281-288
pubmed: 29703998
Psychother Psychosom. 2019;88(1):61-63
pubmed: 30677749
Psychol Med. 2022 Jul;52(10):1959-1968
pubmed: 33272333
Psychoneuroendocrinology. 2014 Jan;39:237-248
pubmed: 24157401
Hum Brain Mapp. 2010 Nov;31(11):1713-26
pubmed: 20725910
PLoS Med. 2015 Mar 31;12(3):e1001779
pubmed: 25826379
Neuroimage. 2016 Jul 1;134:410-423
pubmed: 27039701
Psychoneuroendocrinology. 2013 May;38(5):612-25
pubmed: 23265311
Neuroimage. 2005 May 1;25(4):1325-35
pubmed: 15850749
Psychoneuroendocrinology. 2013 Feb;38(2):171-8
pubmed: 22721608
Biol Psychiatry. 2017 Dec 15;82(12):885-894
pubmed: 28629540
Dev Cogn Neurosci. 2011 Apr;1(2):187-97
pubmed: 21516202
Neuroimage. 2006 Apr 1;30(2):452-61
pubmed: 16326115
Neuroscience. 2021 Apr 1;459:153-165
pubmed: 33484821
iScience. 2021 Nov 16;24(12):103450
pubmed: 34877505
Neuroimage. 2015 Sep;118:154-62
pubmed: 26057590
Sci Rep. 2018 Apr 3;8(1):5476
pubmed: 29615788
Soc Cogn Affect Neurosci. 2017 Aug 1;12(8):1325-1333
pubmed: 28444316
Neuropsychopharmacology. 2016 Apr;41(5):1286-96
pubmed: 26346640
Proc Natl Acad Sci U S A. 2020 May 26;117(21):11781-11787
pubmed: 32385158