Long-term exposure to elemental components of fine particulate matter and all-natural and cause-specific mortality in a Danish nationwide administrative cohort study.

Humans Air Pollutants / analysis Air Pollution / statistics & numerical data Cause of Death Cohort Studies Denmark / epidemiology Environmental Exposure / analysis Lung Neoplasms / mortality Nickel Particulate Matter / analysis Renal Insufficiency, Chronic / mortality Respiratory Tract Diseases / mortality Zinc / analysis Mortality

Air pollution Cox proportional regression model Denmark Long-term exposure Mortality PM(2.5) elemental components

Journal

Environmental research

ISSN: 1096-0953

Titre abrégé: Environ Res

Pays: Netherlands

ID NLM: 0147621

Informations de publication

Date de publication:
01 05 2023

Historique:

received: 30 11 2022

revised: 08 02 2023

accepted: 21 02 2023

pubmed: 24 2 2023

medline: 15 3 2023

entrez: 23 2 2023

Statut: ppublish

Résumé

Fine particulate matter (PM We evaluated the associations between mortality and long-term exposure to eight PM Of 3,081,244 individuals, we observed 803,373 death from natural causes during follow-up. We found significant positive associations between all-natural mortality with Si and K from both exposure modeling approaches (hazard ratios; 95% confidence intervals per interquartile range increase): SLR-Si (1.04; 1.03-1.05), RF-Si (1.01; 1.00-1.02), SLR-K (1.03; 1.02-1.04), and RF-K (1.06; 1.05-1.07). Strong associations of K and Si were detected with most causes of mortality except CKD and K, and diabetes and Si (the strongest associations for psychiatric disorders mortality). In addition, Fe was relevant for mortality from RD, lung cancer, CKD, and psychiatric disorders; Zn with mortality from CKD, RD, and lung cancer, and; Ni and V with lung cancer mortality. We present novel results of the relevance of different PM

Sections du résumé

BACKGROUND

Fine particulate matter (PM

METHODS

We evaluated the associations between mortality and long-term exposure to eight PM

RESULTS

Of 3,081,244 individuals, we observed 803,373 death from natural causes during follow-up. We found significant positive associations between all-natural mortality with Si and K from both exposure modeling approaches (hazard ratios; 95% confidence intervals per interquartile range increase): SLR-Si (1.04; 1.03-1.05), RF-Si (1.01; 1.00-1.02), SLR-K (1.03; 1.02-1.04), and RF-K (1.06; 1.05-1.07). Strong associations of K and Si were detected with most causes of mortality except CKD and K, and diabetes and Si (the strongest associations for psychiatric disorders mortality). In addition, Fe was relevant for mortality from RD, lung cancer, CKD, and psychiatric disorders; Zn with mortality from CKD, RD, and lung cancer, and; Ni and V with lung cancer mortality.

CONCLUSIONS

We present novel results of the relevance of different PM

Identifiants

DOI: 10.1016/j.envres.2023.115552 PMID: 36822536

pubmed: 36822536

pii: S0013-9351(23)00344-4

doi: 10.1016/j.envres.2023.115552

pii:

doi:

Substances chimiques

Air Pollutants 0

Nickel 7OV03QG267

Particulate Matter 0

Zinc J41CSQ7QDS

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

Pagination

115552

Informations de copyright

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.