Spondyloocular Syndrome: A Report of an Additional Family and Phenotypic Spectrum Delineation.

Lebanon XYLT2 ocular disorders skeletal disorders spondyloocular syndrome whole exome sequencing

Journal

Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097

Informations de publication

Date de publication:
15 02 2023
Historique:
received: 28 01 2023
revised: 08 02 2023
accepted: 13 02 2023
entrez: 25 2 2023
pubmed: 26 2 2023
medline: 3 3 2023
Statut: epublish

Résumé

Spondyloocular syndrome (SOS, OMIM # 605822) is a rare genetic disorder characterized by osseous and ocular manifestations, including generalized osteoporosis, multiple long bones fractures, platyspondyly, dense cataracts and retinal detachment, and dysmorphic facial features, with or without short stature, cardiopathy, hearing impairment, and intellectual disability. Biallelic mutations in the

Identifiants

pubmed: 36833424
pii: genes14020497
doi: 10.3390/genes14020497
pmc: PMC9957273
pii:
doi:

Substances chimiques

Codon, Nonsense 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Références

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Auteurs

Eliane Chouery (E)

Department of Human Genetics, Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos P.O. Box 13-5053, Lebanon.

Rim Karam (R)

Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos P.O. Box 13-5053, Lebanon.

Yves Najm Mrad (YN)

Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos P.O. Box 13-5053, Lebanon.

Cybel Mehawej (C)

Department of Human Genetics, Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos P.O. Box 13-5053, Lebanon.

Nahia Dib El Jalbout (N)

Department of Ophthalmology, Lebanese American University Medical Center, Rizk Hospital, Beirut P.O. Box 13-5053, Lebanon.

Jamal Bleik (J)

Department of Ophthalmology, Lebanese American University Medical Center, Rizk Hospital, Beirut P.O. Box 13-5053, Lebanon.

Daniel Mahfoud (D)

Department of Radiology, Gilbert and Rose-Marie Ghagoury School of Medicine, Lebanese American University, Byblos P.O. Box 13-5053, Lebanon.

Andre Megarbane (A)

Department of Human Genetics, Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos P.O. Box 13-5053, Lebanon.
Institut Jérôme Lejeune, 75015 Paris, France.

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