Fluro-Protein C-Phycocyanin Docked Silver Nanocomposite Accelerates Cell Migration through NFĸB Signaling Pathway.
NFĸB pathway
cell migration
cell proliferation
fibroblast cells
silver doped C-phycocyanin (AgcPCNP)
wound healing
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
06 Feb 2023
06 Feb 2023
Historique:
received:
26
12
2022
revised:
23
01
2023
accepted:
31
01
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
3
3
2023
Statut:
epublish
Résumé
Currently, there is a great demand for the development of nanomedicine aided wound tissue regeneration via silver doped nanoceuticals. Unfortunately, very little research is being carried out on antioxidants-doped silver nanometals and their interaction on the signaling axis during the bio-interface mechanism. In this study, c-phycocyanin primed silver nano hybrids (AgcPCNP) were prepared and analyzed for properties such as cytotoxicity, metal decay, nanoconjugate stability, size expansion, and antioxidant features. Fluctuations in the expression of marker genes during cell migration phenomena in in vitro wound healing scenarios were also validated. Studies revealed that physiologically relevant ionic solutions did not exhibit any adverse effects on the nanoconjugate stability. However, acidic, alkali, and ethanol solutions completely denatured the AgcPCNP conjugates. Signal transduction RT
Identifiants
pubmed: 36834597
pii: ijms24043184
doi: 10.3390/ijms24043184
pmc: PMC9962756
pii:
doi:
Substances chimiques
Silver
3M4G523W1G
Phycocyanin
11016-15-2
Phosphatidylinositol 3-Kinases
EC 2.7.1.-
Protein C
0
Nanoconjugates
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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