Impact of Preoperative Immunonutrition on Oxidative Stress and Gut Barrier Function in Surgical Patients with Crohn's Disease.
AGEs
AOPP
Crohn’s disease
RAGE
barrier function
immunonutrition
oxidative stress
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
09 Feb 2023
09 Feb 2023
Historique:
received:
29
12
2022
revised:
02
02
2023
accepted:
07
02
2023
entrez:
25
2
2023
pubmed:
26
2
2023
medline:
3
3
2023
Statut:
epublish
Résumé
Several international guidelines recommend a peri-operative immunonutrition (IN) support for patients care in elective colorectal surgery, to reduce postoperative complications, particularly infections. In Crohn's patients, is also used to mitigate the severity of the disease. We performed a pilot study on 16 Crohn's patients undergoing intestinal surgery for active disease, not responsive to pharmacological treatment; half of them received an oral nutritional supplement enriched with immunonutrients (IN patients) for 7 days prior to surgery, in addition to normal food intake. Markers of oxidative stress (Advanced Glycated End-products (AGEs) and Advanced Oxidation Protein Products (AOPPs) were measured both in plasma and tissue samples wherein the Receptor for Advanced Glycation End products (RAGE) and Tight Junction Protein 1 (TJP1) gene expression were also determined. Plasma AGEs were significantly and positively correlated with tissue levels of AGEs (
Identifiants
pubmed: 36839239
pii: nu15040882
doi: 10.3390/nu15040882
pmc: PMC9960923
pii:
doi:
Substances chimiques
Advanced Oxidation Protein Products
0
Glycation End Products, Advanced
0
Receptor for Advanced Glycation End Products
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ente Cassa di Risparmio di Firenze
ID : CRF2018, 2016.0842
Organisme : European Crohn's and Colitis Organisation
ID : ECCO Grant 2020
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