HLA-DMB alleles and haplotypes in Ecuador (Cuenca) Amerindians: Importance for HLA and disease studies.
Amerindians
Arthritis
Autoimmunity
CLIP
Diabetes
Diseases
Ecuador
HLA-DM
HLA-DMB
HLA-DO
HLA-DQB1
HLA-DRB1
Psoriasis
SLE
Journal
Human immunology
ISSN: 1879-1166
Titre abrégé: Hum Immunol
Pays: United States
ID NLM: 8010936
Informations de publication
Date de publication:
Apr 2023
Apr 2023
Historique:
received:
15
02
2023
revised:
16
02
2023
accepted:
17
02
2023
medline:
3
4
2023
pubmed:
5
3
2023
entrez:
4
3
2023
Statut:
ppublish
Résumé
HLA-DMB allele frequencies and HLA-DBM-DRB1-DQB1 extended haplotypes were studied for the first time in Amerindians (Cuenca city area, Ecuador). It was found that most common extended haplotypes gathered the most frequent HLA-DRB1 Amerindian alleles. HLA-DMB polymorphism studies may be important to uncover HLA and diseases pathogenesis and also in an extended HLA haplotype frameshift. HLA-DM molecule has a crucial role together with CLIP protein in HLA class II peptide presentation. HLA extended haplotypes including complement and non classical genes alleles are proposed to HLA and disease studies.
Identifiants
pubmed: 36870854
pii: S0198-8859(23)00040-X
doi: 10.1016/j.humimm.2023.02.004
pii:
doi:
Substances chimiques
HLA-D Antigens
0
HLA-DM antigens
0
HLA-DQ Antigens
0
HLA-DQ beta-Chains
0
HLA-DRB1 Chains
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
261-262Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.