Design and Biochemical Characterization of Peptidic Inhibitors of the Myb/p300 Interaction.

Peptides / pharmacology Protein Binding Proto-Oncogene Proteins c-myb / antagonists & inhibitors E1A-Associated p300 Protein / antagonists & inhibitors

Journal

Biochemistry
ISSN: 1520-4995
Titre abrégé: Biochemistry
Pays: United States
ID NLM: 0370623

Informations de publication

Date de publication:
04 04 2023
Historique:
medline: 5 4 2023
pubmed: 9 3 2023
entrez: 8 3 2023
Statut: ppublish

Résumé

The Myb transcription factor is involved in the proliferation of hematopoietic cells, and deregulation of its expression can lead to cancers such as leukemia. Myb interacts with various proteins, including the histone acetyltransferases p300 and CBP. Myb binds to a small domain of p300, the KIX domain (p300

Identifiants

DOI: 10.1021/acs.biochem.2c00690 PMID: 36883372
pubmed: 36883372
doi: 10.1021/acs.biochem.2c00690
doi:

Substances chimiques

Peptides 0
Proto-Oncogene Proteins c-myb 0
E1A-Associated p300 Protein EC 2.3.1.48

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1321-1329

Auteurs

Matthew Jones (M)

Disease Area Oncology, Novartis Institutes for Biomedical Research, Basel CH-4002, Switzerland.

Philipp Grosche (P)

Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Basel CH-4002, Switzerland.

Andreas Floersheimer (A)

Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Basel CH-4002, Switzerland.

Jérome André (J)

Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Basel CH-4002, Switzerland.

Raphael Gattlen (R)

Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Basel CH-4002, Switzerland.

Dieter Oser (D)

Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Basel CH-4002, Switzerland.

Juliette Tinchant (J)

Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Basel CH-4002, Switzerland.

Roman Wille (R)

Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Basel CH-4002, Switzerland.

Barbara Chie-Leon (B)

Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, Emeryville, California 94608, United States.

Marc Gerspacher (M)

Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Basel CH-4002, Switzerland.

Peter Ertl (P)

Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Basel CH-4002, Switzerland.
ORCID: 0000-0001-6496-4448

Nils Ostermann (N)

Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, Emeryville, California 94608, United States.
ORCID: 0000-0002-3391-1228

Eva Altmann (E)

Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Basel CH-4002, Switzerland.
ORCID: 0000-0002-2749-6347

Eusebio Manchado (E)

Disease Area Oncology, Novartis Institutes for Biomedical Research, Basel CH-4002, Switzerland.

Thomas Vorherr (T)

Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Basel CH-4002, Switzerland.

Patrick Chène (P)

Disease Area Oncology, Novartis Institutes for Biomedical Research, Basel CH-4002, Switzerland.
ORCID: 0000-0002-6010-9169

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Design and Biochemical Characterization of...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Design and Biochemical Characterization of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines proto-oncogènes c-myb › Design and Biochemical Characterization of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription CBP-p300 › Protéine p300-E1A › Design and Biochemical Characterization of...