Macrophage fumarate hydratase restrains mtRNA-mediated interferon production.
Humans
Argininosuccinate Synthase
/ metabolism
Argininosuccinic Acid
/ metabolism
Aspartic Acid
/ metabolism
Cell Respiration
Cytosol
/ metabolism
Fumarate Hydratase
/ antagonists & inhibitors
Fumarates
/ metabolism
Interferon-beta
/ biosynthesis
Lipopolysaccharides
/ pharmacology
Lupus Erythematosus, Systemic
/ enzymology
Macrophages
/ enzymology
Membrane Potential, Mitochondrial
Metabolomics
Mitochondria
/ genetics
RNA, Mitochondrial
/ metabolism
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
03 2023
03 2023
Historique:
received:
01
03
2022
accepted:
10
01
2023
pubmed:
9
3
2023
medline:
21
3
2023
entrez:
8
3
2023
Statut:
ppublish
Résumé
Metabolic rewiring underlies the effector functions of macrophages
Identifiants
pubmed: 36890227
doi: 10.1038/s41586-023-05720-6
pii: 10.1038/s41586-023-05720-6
pmc: PMC10411300
mid: NIHMS1910116
doi:
Substances chimiques
Argininosuccinate Synthase
EC 6.3.4.5
Argininosuccinic Acid
2387-71-5
Aspartic Acid
30KYC7MIAI
RIGI protein, human
EC 3.6.1.-
Fumarate Hydratase
EC 4.2.1.2
Fumarates
0
IFIH1 protein, human
EC 3.6.1.-
Interferon-beta
77238-31-4
Lipopolysaccharides
0
RNA, Mitochondrial
0
TLR7 protein, human
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
490-498Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI164504
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS126851
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature Limited.
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