Development of Clioquinol Platinum(IV) Conjugates as Autophagy-Targeted Antimetastatic Agents.

Platinum / pharmacology Clioquinol / pharmacology Phosphatidylinositol 3-Kinases / metabolism Proto-Oncogene Proteins c-akt / metabolism CD8-Positive T-Lymphocytes / metabolism Antineoplastic Agents / pharmacology Apoptosis Autophagy Cell Line, Tumor

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
09 03 2023
Historique:
entrez: 9 3 2023
pubmed: 10 3 2023
medline: 11 3 2023
Statut: ppublish

Résumé

A series of autophagy-targeted antimetastatic clioquinol (CLQ) platinum(IV) conjugates were designed and prepared by incorporating an autophagy activator CLQ into the platinum(IV) system. Complex

Identifiants

DOI: 10.1021/acs.jmedchem.2c01895 PMID: 36891739
pubmed: 36891739
doi: 10.1021/acs.jmedchem.2c01895
doi:

Substances chimiques

Platinum 49DFR088MY
Clioquinol 7BHQ856EJ5
Phosphatidylinositol 3-Kinases EC 2.7.1.-
Proto-Oncogene Proteins c-akt EC 2.7.11.1
Antineoplastic Agents 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3393-3410

Auteurs

Ming Zhang (M)

Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng 252059, P. R. China.

Linming Li (L)

Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng 252059, P. R. China.

Suying Li (S)

Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng 252059, P. R. China.

Zhifang Liu (Z)

Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng 252059, P. R. China.

Ning Zhang (N)

Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng 252059, P. R. China.
ORCID: 0000-0003-2102-8611

Bin Sun (B)

Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng 252059, P. R. China.

Zhengping Wang (Z)

Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng 252059, P. R. China.
Liaocheng High-Tech Biotechnology Co., Ltd, Liaocheng 252059, P. R. China.

Dianlong Jia (D)

School of Pharmacy, Liaocheng University, Liaocheng, Shandong 252059, P. R. China.

Min Liu (M)

Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng 252059, P. R. China.
ORCID: 0000-0002-1918-9072

Qingpeng Wang (Q)

Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng 252059, P. R. China.
ORCID: 0000-0002-2093-8237

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Classifications MeSH

questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Platine › Development of Clioquinol Platinum(IV)...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Hydroxyquinoléines › Hydroxy-8 quinoléine › Clioquinol › Development of Clioquinol Platinum(IV)...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphatidylinositol 3-kinases › Development of Clioquinol Platinum(IV)...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-akt › Development of Clioquinol Platinum(IV)...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Development of Clioquinol Platinum(IV)...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Development of Clioquinol Platinum(IV)...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Development of Clioquinol Platinum(IV)...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Autophagie › Development of Clioquinol Platinum(IV)...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Development of Clioquinol Platinum(IV)...