ICAMs are dispensable for influenza clearance and anti-viral humoral and cellular immunity.

Mice Animals Humans Intercellular Adhesion Molecule-1 / metabolism CD8-Positive T-Lymphocytes Antiviral Agents Influenza A Virus, H1N1 Subtype / metabolism Influenza, Human Cell Adhesion Molecules / metabolism Immunity, Cellular Antigens, CD / metabolism
endothelium inflammation integrins leukocyte trafficking memory

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2022
Historique:
received: 11 09 2022
accepted: 12 12 2022
entrez: 10 3 2023
pubmed: 11 3 2023
medline: 14 3 2023
Statut: epublish

Résumé

αLβ2 (LFA-1) mediated interactions with ICAM-1 and ICAM-2 predominate leukocyte-vascular interactions, but their functions in extravascular cell-cell communications is still debated. The roles of these two ligands in leukocyte trafficking, lymphocyte differentiation, and immunity to influenza infections were dissected in the present study. Surprisingly, double ICAM-1 and ICAM-2 knock out mice (herein ICAM-1/2

Identifiants

DOI: 10.3389/fimmu.2022.1041552 PMID: 36895258 PMC: PMC9988921
pubmed: 36895258
doi: 10.3389/fimmu.2022.1041552
pmc: PMC9988921
doi:

Substances chimiques

Intercellular Adhesion Molecule-1 126547-89-5
Antiviral Agents 0
Cell Adhesion Molecules 0
ICAM-2 protein, mouse 0
Antigens, CD 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1041552

Informations de copyright

Copyright © 2023 Kozlovski, Regev, Sapoznikov, Kizner, Achdout, Petrovich-Kopitman, Elkahal, Addadi, Silva Castanheira, Feigelson, Kubes, Erez, Garbi and Alon.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Stav Kozlovski (S)

Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.

Ofer Regev (O)

Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.

Anita Sapoznikov (A)

Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona, Israel.

Marina Kizner (M)

Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.

Hagit Achdout (H)

Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona, Israel.

Ekaterina Petrovich-Kopitman (E)

Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel.

Jacob Elkahal (J)

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

Yoseph Addadi (Y)

Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel.

Fernanda Vargas E Silva Castanheira (FVE)

Department of Pharmacology and Physiology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Sara W Feigelson (SW)

Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.

Paul Kubes (P)

Department of Pharmacology and Physiology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Noam Erez (N)

Department of Biochemistry and Molecular Genetics, Israel Institute for Biological Research, Ness-Ziona, Israel.

Natalio Garbi (N)

Department of Cellular Immunology, Institute of Experimental Immunology Medical Faculty, University of Bonn, Bonn, Germany.

Ronen Alon (R)

Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › ICAMs are dispensable for influenza clearance...
questionsmedicales.fr › Eucaryotes › Animaux › ICAMs are dispensable for influenza clearance...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › ICAMs are dispensable for influenza clearance...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Molécules d'adhérence cellulaire › Molécule-1 d'adhérence intercellulaire › ICAMs are dispensable for influenza clearance...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › ICAMs are dispensable for influenza clearance...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › ICAMs are dispensable for influenza clearance...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN de polarité négative › Orthomyxoviridae › Influenzavirus A › Virus de la grippe A › Sous-type H1N1 du virus de la grippe A › ICAMs are dispensable for influenza clearance...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Grippe humaine › ICAMs are dispensable for influenza clearance...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Molécules d'adhérence cellulaire › ICAMs are dispensable for influenza clearance...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Immunité cellulaire › ICAMs are dispensable for influenza clearance...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes CD › ICAMs are dispensable for influenza clearance...