Computational modeling of cambium activity provides a regulatory framework for simulating radial plant growth.
A. thaliana
computational biology
organ growth
plant biology
stem cell regulation
wood formation
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
10 03 2023
10 03 2023
Historique:
received:
17
01
2021
accepted:
06
03
2023
medline:
5
4
2023
pubmed:
11
3
2023
entrez:
10
3
2023
Statut:
epublish
Résumé
Precise organization of growing structures is a fundamental process in developmental biology. In plants, radial growth is mediated by the cambium, a stem cell niche continuously producing wood (xylem) and bast (phloem) in a strictly bidirectional manner. While this process contributes large parts to terrestrial biomass, cambium dynamics eludes direct experimental access due to obstacles in live-cell imaging. Here, we present a cell-based computational model visualizing cambium activity and integrating the function of central cambium regulators. Performing iterative comparisons of plant and model anatomies, we conclude that the receptor-like kinase PXY and its ligand CLE41 are part of a minimal framework sufficient for instructing tissue organization. By integrating tissue-specific cell wall stiffness values, we moreover probe the influence of physical constraints on tissue geometry. Our model highlights the role of intercellular communication within the cambium and shows that a limited number of factors are sufficient to create radial growth by bidirectional tissue production.
Identifiants
pubmed: 36897801
doi: 10.7554/eLife.66627
pii: 66627
pmc: PMC10069871
doi:
pii:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2023, Lebovka et al.
Déclaration de conflit d'intérêts
IL, BH, XL, AZ, TS, NG, RM, RG, TG No competing interests declared
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