Ferric Pyrophosphate Forms Soluble Iron Coordination Complexes with Zinc Compounds and Solubilizing Agents in Extruded Rice and Predicts Increased Iron Solubility and Bioavailability in Young Women.
bioavailability
electron paramagnetic resonance
extrusion
fortification
iron absorption
iron deficiency
rice
solubilizing agent
women
Journal
The Journal of nutrition
ISSN: 1541-6100
Titre abrégé: J Nutr
Pays: United States
ID NLM: 0404243
Informations de publication
Date de publication:
03 2023
03 2023
Historique:
received:
16
08
2022
revised:
03
12
2022
accepted:
14
12
2022
pmc-release:
24
12
2023
entrez:
17
3
2023
pubmed:
18
3
2023
medline:
22
3
2023
Statut:
ppublish
Résumé
Co-extrusion of ferric pyrophosphate (FePP) with solubilizers, citric acid/trisodium citrate (CA/TSC), or ethylenediaminetetraacetic acid (EDTA) sharply increases iron absorption. Whether this can protect against the inhibition of iron absorption by phytic acid (PA) is unclear. Sodium pyrophosphate (NaPP) may be a new enhancer of iron absorption from FePP. Our objectives were to 1) investigate the ligand coordination of iron, zinc, and solubilizers in extruded rice and test associations with iron solubility and absorption, 2) assess whether co-extrusion of FePP + CA/TSC rice can protect against inhibition of iron absorption by PA; 3) determine the effect of zinc oxide (ZnO) compared with zinc sulfate (ZnSO We produced labeled The addition of zinc and solubilizers created new iron coordination complexes of Fe(III) species with a weak ligand field at a high-spin state that correlated with solubility (r Rice extrusion of FePP with solubilizers resulted in bioavailable iron coordination complexes. In the case of FePP + CA/TSC, PA exerted similar inhibition of FIA as with FeSO
Sections du résumé
BACKGROUND
Co-extrusion of ferric pyrophosphate (FePP) with solubilizers, citric acid/trisodium citrate (CA/TSC), or ethylenediaminetetraacetic acid (EDTA) sharply increases iron absorption. Whether this can protect against the inhibition of iron absorption by phytic acid (PA) is unclear. Sodium pyrophosphate (NaPP) may be a new enhancer of iron absorption from FePP.
OBJECTIVES
Our objectives were to 1) investigate the ligand coordination of iron, zinc, and solubilizers in extruded rice and test associations with iron solubility and absorption, 2) assess whether co-extrusion of FePP + CA/TSC rice can protect against inhibition of iron absorption by PA; 3) determine the effect of zinc oxide (ZnO) compared with zinc sulfate (ZnSO
METHODS
We produced labeled
RESULTS
The addition of zinc and solubilizers created new iron coordination complexes of Fe(III) species with a weak ligand field at a high-spin state that correlated with solubility (r
CONCLUSION
Rice extrusion of FePP with solubilizers resulted in bioavailable iron coordination complexes. In the case of FePP + CA/TSC, PA exerted similar inhibition of FIA as with FeSO
Identifiants
pubmed: 36931746
pii: S0022-3166(22)13246-3
doi: 10.1016/j.tjnut.2022.12.003
pmc: PMC10127525
pii:
doi:
Substances chimiques
ferric pyrophosphate
QK8899250F
Coordination Complexes
0
Zinc Compounds
0
Zinc Oxide
SOI2LOH54Z
Ferric Compounds
0
Edetic Acid
9G34HU7RV0
Phytic Acid
7IGF0S7R8I
Ligands
0
Iron
E1UOL152H7
Ferrous Compounds
0
Zinc
J41CSQ7QDS
Banques de données
ClinicalTrials.gov
['NCT03703739']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
636-644Informations de copyright
Copyright © 2022 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.
Références
Food Chem. 2016 Oct 1;208:97-102
pubmed: 27132828
J Nutr. 2017 Mar;147(3):377-383
pubmed: 28148685
Br J Nutr. 2000 Dec;84(6):903-10
pubmed: 11177208
J Nutr. 2019 May 1;149(5):723-729
pubmed: 31004134
Can Vet J. 2012 Mar;53(3):250-6
pubmed: 22942439
Am J Clin Nutr. 1981 Oct;34(10):2248-56
pubmed: 6794346
Ann N Y Acad Sci. 2014 Sep;1324:55-66
pubmed: 25091403
Sci Adv. 2019 Mar 27;5(3):eaau0790
pubmed: 30944850
J Agric Food Chem. 2009 Jun 10;57(11):5014-9
pubmed: 19449807
Ann N Y Acad Sci. 2014 Sep;1324:29-39
pubmed: 24913257
Int J Vitam Nutr Res. 2004 Nov;74(6):421-34
pubmed: 15743018
Dalton Trans. 2009 Oct 28;(40):8616-25
pubmed: 19809738
Br J Nutr. 2016 Aug;116(3):496-503
pubmed: 27267429
Phys Chem Chem Phys. 2017 Sep 20;19(36):24769-24791
pubmed: 28868562
Front Chem. 2020 Sep 23;8:582746
pubmed: 33173770
J Nutr. 2022 May 5;152(5):1220-1227
pubmed: 34967894
J Nutr. 2014 Sep;144(9):1467-73
pubmed: 24966411
Am J Clin Nutr. 2009 Nov;90(5):1280-7
pubmed: 19740974
Dalton Trans. 2006 Oct 7;(37):4415-34
pubmed: 16981015
J Nutr. 2013 Sep;143(9):1376-82
pubmed: 23884388
Am J Clin Nutr. 2016 May;103(5):1252-9
pubmed: 27053382