Oxime@Zirconium-Metal-Organic Framework Hybrid Material as a Potential Antidote for Organophosphate Poisoning.
Journal
Inorganic chemistry
ISSN: 1520-510X
Titre abrégé: Inorg Chem
Pays: United States
ID NLM: 0366543
Informations de publication
Date de publication:
03 Apr 2023
03 Apr 2023
Historique:
medline:
4
4
2023
pubmed:
21
3
2023
entrez:
20
3
2023
Statut:
ppublish
Résumé
A novel material with dual activity toward organophosphate (OP) poisoning, based on Zr-MOF-808 and neutral oxime RS69N, has been prepared. The hybrid material has a significant drug payload (5.2 ± 0.9 oxime to MOF-808 molar ratio) and shows a sustained oxime release in simulated physiological media, leading to the successful reactivation of OP-inhibited acetylcholinesterase. At the same time, the hybrid system presents an efficient and moderately fast removal rate of a toxic organophosphorus model compound (diisopropylfluorophosphate) from simulated physiological media (
Identifiants
pubmed: 36939843
doi: 10.1021/acs.inorgchem.3c00121
pmc: PMC10074384
doi:
Substances chimiques
Oximes
0
Antidotes
0
Cholinesterase Reactivators
0
Metal-Organic Frameworks
0
Zirconium
C6V6S92N3C
Acetylcholinesterase
EC 3.1.1.7
Cholinesterase Inhibitors
0
Organophosphorus Compounds
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5049-5053Références
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