Cellular mechanisms of heterogeneity in NF2-mutant schwannoma.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
21 03 2023
21 03 2023
Historique:
received:
01
10
2021
accepted:
06
03
2023
entrez:
22
3
2023
pubmed:
23
3
2023
medline:
24
3
2023
Statut:
epublish
Résumé
Schwannomas are common sporadic tumors and hallmarks of familial neurofibromatosis type 2 (NF2) that develop predominantly on cranial and spinal nerves. Virtually all schwannomas result from inactivation of the NF2 tumor suppressor gene with few, if any, cooperating mutations. Despite their genetic uniformity schwannomas exhibit remarkable clinical and therapeutic heterogeneity, which has impeded successful treatment. How heterogeneity develops in NF2-mutant schwannomas is unknown. We have found that loss of the membrane:cytoskeleton-associated NF2 tumor suppressor, merlin, yields unstable intrinsic polarity and enables Nf2
Identifiants
pubmed: 36944680
doi: 10.1038/s41467-023-37226-0
pii: 10.1038/s41467-023-37226-0
pmc: PMC10030849
doi:
Substances chimiques
Neurofibromin 2
0
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1559Subventions
Organisme : NIH HHS
ID : S10 OD025017
Pays : United States
Informations de copyright
© 2023. The Author(s).
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