The intriguing molecular dynamics of Cer[EOS] in rigid skin barrier lipid layers requires improvement of the model.
NMR spectroscopy
lipid assembly
lipid chain order
long periodicity phase
molecular dynamics
neutron diffraction
stratum corneum models
Journal
Journal of lipid research
ISSN: 1539-7262
Titre abrégé: J Lipid Res
Pays: United States
ID NLM: 0376606
Informations de publication
Date de publication:
05 2023
05 2023
Historique:
received:
23
01
2023
revised:
07
03
2023
accepted:
08
03
2023
medline:
26
5
2023
pubmed:
23
3
2023
entrez:
22
3
2023
Statut:
ppublish
Résumé
Omega-O-acyl ceramides such as 32-linoleoyloxydotriacontanoyl sphingosine (Cer[EOS]) are essential components of the lipid skin barrier, which protects our body from excessive water loss and the penetration of unwanted substances. These ceramides drive the lipid assembly to epidermal-specific long periodicity phase (LPP), structurally much different than conventional lipid bilayers. Here, we synthesized Cer[EOS] with selectively deuterated segments of the ultralong N-acyl chain or deuterated or
Identifiants
pubmed: 36948272
pii: S0022-2275(23)00029-9
doi: 10.1016/j.jlr.2023.100356
pmc: PMC10154977
pii:
doi:
Substances chimiques
Linoleic Acid
9KJL21T0QJ
Sphingosine
NGZ37HRE42
Ceramides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
100356Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest The authors declare that they have no conflicts of interest with the contents of this article.