Chemical and structural approaches to investigate PTEN function and regulation.

Biomolecular NMR C-terminal tail Expressed protein ligation PTEN Phosphorylation Protein X-ray crystallography

Journal

Methods in enzymology
ISSN: 1557-7988
Titre abrégé: Methods Enzymol
Pays: United States
ID NLM: 0212271

Informations de publication

Date de publication:
2023
Historique:
pmc-release: 01 01 2024
entrez: 22 3 2023
pubmed: 23 3 2023
medline: 25 3 2023
Statut: ppublish

Résumé

Phosphatase and tensin homolog is a lipid phosphatase that serves as the major negative regulator of the PI3K/AKT pathway. It catalyzes the 3'-specific dephosphorylation of phosphatidylinositol (3,4,5)-trisphosphate (PIP

Identifiants

pubmed: 36948705
pii: S0076-6879(22)00388-3
doi: 10.1016/bs.mie.2022.09.007
pmc: PMC10037535
mid: NIHMS1862022
pii:
doi:

Substances chimiques

Phosphatidylinositol 3-Kinases EC 2.7.1.-
PTEN Phosphohydrolase EC 3.1.3.67
Amino Acids 0
Lipids 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

289-318

Subventions

Organisme : NIGMS NIH HHS
ID : R00 GM130961
Pays : United States

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

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Auteurs

Thibault Viennet (T)

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, United States; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, United States.

Santiago Rodriguez Ospina (S)

Department of Dermatology, Boston University School of Medicine, Boston, MA, United States; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, United States.

Yunqi Lu (Y)

Department of Dermatology, Boston University School of Medicine, Boston, MA, United States; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, United States.

Anna Cui (A)

Department of Dermatology, Boston University School of Medicine, Boston, MA, United States; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, United States.

Haribabu Arthanari (H)

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, United States; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, United States.

Daniel R Dempsey (DR)

Department of Dermatology, Boston University School of Medicine, Boston, MA, United States; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, United States. Electronic address: ddempsey@bu.edu.

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Classifications MeSH