Temsavir blocks the immunomodulatory activities of HIV-1 soluble gp120.

HIV-1 CD4-Positive T-Lymphocytes / metabolism Down-Regulation HIV Envelope Protein gp120 Cytokines / metabolism
ADCC BMS-626529 BMS-663068 Env glycoprotein HIV-1 attachment inhibitors cytokine burst fostemsavir soluble gp120 temsavir

Journal

Cell chemical biology
ISSN: 2451-9448
Titre abrégé: Cell Chem Biol
Pays: United States
ID NLM: 101676030

Informations de publication

Date de publication:
18 05 2023
Historique:
received: 14 10 2022
revised: 03 02 2023
accepted: 02 03 2023
pmc-release: 18 05 2024
medline: 22 5 2023
pubmed: 24 3 2023
entrez: 23 3 2023
Statut: ppublish

Résumé

While HIV-1-mediated CD4 downregulation protects infected cells from antibody-dependent cellular cytotoxicity (ADCC), shed gp120 binds to CD4 on uninfected bystander CD4

Identifiants

DOI: 10.1016/j.chembiol.2023.03.003 PMID: 36958337 PMC: PMC10198848
pubmed: 36958337
pii: S2451-9456(23)00062-4
doi: 10.1016/j.chembiol.2023.03.003
pmc: PMC10198848
mid: NIHMS1882593
pii:
doi:

Substances chimiques

HIV Envelope Protein gp120 0
Cytokines 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

540-552.e6

Subventions

Organisme : NIAID NIH HHS
ID : P01 AI150471
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI129769
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI148379
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI150322
Pays : United States

Informations de copyright

Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests W.M. and A.F. received funding from ViiV Healthcare. A.C. is a full-time employee of ViiV Healthcare.

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Auteurs

Jonathan Richard (J)

Centre de Recherche du CHUM, Montréal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie, et Immunologie, Université de Montréal, Montréal, QC H2X 0A9, Canada.

Jérémie Prévost (J)

Centre de Recherche du CHUM, Montréal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie, et Immunologie, Université de Montréal, Montréal, QC H2X 0A9, Canada.

Catherine Bourassa (C)

Centre de Recherche du CHUM, Montréal, QC H2X 0A9, Canada.

Nathalie Brassard (N)

Centre de Recherche du CHUM, Montréal, QC H2X 0A9, Canada.

Marianne Boutin (M)

Centre de Recherche du CHUM, Montréal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie, et Immunologie, Université de Montréal, Montréal, QC H2X 0A9, Canada.

Mehdi Benlarbi (M)

Centre de Recherche du CHUM, Montréal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie, et Immunologie, Université de Montréal, Montréal, QC H2X 0A9, Canada.

Guillaume Goyette (G)

Centre de Recherche du CHUM, Montréal, QC H2X 0A9, Canada.

Halima Medjahed (H)

Centre de Recherche du CHUM, Montréal, QC H2X 0A9, Canada.

Gabrielle Gendron-Lepage (G)

Centre de Recherche du CHUM, Montréal, QC H2X 0A9, Canada.

Fleur Gaudette (F)

Plateforme de Pharmacocinétique, Centre de Recherche du CHUM, Montréal, QC H2X 0A9, Canada.

Hung-Ching Chen (HC)

Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104-6323, USA.

William D Tolbert (WD)

Infectious Diseases Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4712, USA.

Amos B Smith (AB)

Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104-6323, USA.

Marzena Pazgier (M)

Infectious Diseases Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4712, USA.

Mathieu Dubé (M)

Centre de Recherche du CHUM, Montréal, QC H2X 0A9, Canada.

Andrew Clark (A)

ViiV Healthcare, Global Medical Affairs, Middlesex TW8 9GS, UK.

Walther Mothes (W)

Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06510, USA.

Daniel E Kaufmann (DE)

Centre de Recherche du CHUM, Montréal, QC H2X 0A9, Canada; Département de Médecine, Université de Montréal, Montréal, QC H2X 0A9, Canada.

Andrés Finzi (A)

Centre de Recherche du CHUM, Montréal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie, et Immunologie, Université de Montréal, Montréal, QC H2X 0A9, Canada. Electronic address: andres.finzi@umontreal.ca.

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Classifications MeSH

questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › VIH-1 (Virus de l'Immunodéficience Humaine de type 1) › Temsavir blocks the immunomodulatory...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Temsavir blocks the immunomodulatory...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation négative › Temsavir blocks the immunomodulatory...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes viraux › Antigènes du VIH › Protéine d'enveloppe gp120 du VIH › Temsavir blocks the immunomodulatory...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Temsavir blocks the immunomodulatory...