Phospholipase C-ε defines a PACAP-stimulated pathway for secretion in the chromaffin cell.
PACAP
acetylcholine
chromaffin
exocytosis
secretion
Journal
Journal of neuroendocrinology
ISSN: 1365-2826
Titre abrégé: J Neuroendocrinol
Pays: United States
ID NLM: 8913461
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
revised:
15
02
2023
received:
30
12
2022
accepted:
08
03
2023
medline:
23
11
2023
pubmed:
28
3
2023
entrez:
27
3
2023
Statut:
ppublish
Résumé
Adrenomedullary chromaffin cells respond to splanchnic (sympathetic) nerve stimulation by releasing stress hormones into the circulation. The signal for hormone secretion is encoded in the neurotransmitters - especially acetylcholine (ACh) and pituitary adenylate cyclase activating polypeptide (PACAP) - that are released into the splanchnic-chromaffin cell synapse. However, functional differences in the effects of ACh and PACAP on the chromaffin cell secretory response are not well defined. Here, selective agonists of PACAP receptors or nicotinic and muscarinic acetylcholine receptors were applied to chromaffin cells. The major differences in the effects of these agents were not on exocytosis, per se, but rather on the steps upstream of exocytosis. In almost every respect, the properties of individual fusion events triggered by PACAP and cholinergic agonists were similar. On the other hand, the properties of the Ca
Substances chimiques
Acetylcholine
N9YNS0M02X
Catecholamines
0
Cholinergic Agonists
0
Guanine Nucleotide Exchange Factors
0
Hormones
0
Pituitary Adenylate Cyclase-Activating Polypeptide
0
phospholipase C epsilon
EC 3.1.4.11
Receptors, Cholinergic
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13255Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM127303
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS122534
Pays : United States
Organisme : NINDS NIH HHS
ID : R01NS122534
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01GM106569
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35GM127303
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01GM106569
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35GM127303
Pays : United States
Organisme : NINDS NIH HHS
ID : R01NS122534
Pays : United States
Informations de copyright
© 2023 The Authors. Journal of Neuroendocrinology published by John Wiley & Sons Ltd on behalf of British Society for Neuroendocrinology.
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