A Novel Resveratrol-Induced Pathway Increases Neuron-Derived Cell Resilience against Oxidative Stress.
estrogen receptors
gold nanoparticles
neuronal-derived cells
oxidative stress
resveratrol
signal transduction pathways
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
21 Mar 2023
21 Mar 2023
Historique:
received:
27
01
2023
revised:
16
03
2023
accepted:
17
03
2023
medline:
30
3
2023
entrez:
29
3
2023
pubmed:
30
3
2023
Statut:
epublish
Résumé
A promising therapeutic strategy to delay and/or prevent the onset of neurodegenerative diseases (NDs) could be to restore neuroprotective pathways physiologically triggered by neurons against stress injury. Recently, we identified the accumulation of neuroglobin (NGB) in neuronal cells, induced by the 17β-estradiol (E2)/estrogen receptor β (ERβ) axis, as a protective response that increases mitochondria functionality and prevents the activation of apoptosis, increasing neuron resilience against oxidative stress. Here, we would verify if resveratrol (Res), an ERβ ligand, could reactivate NGB accumulation and its protective effects against oxidative stress in neuronal-derived cells (i.e., SH-SY5Y cells). Our results demonstrate that ERβ/NGB is a novel pathway triggered by low Res concentrations that lead to rapid and persistent NGB accumulation in the cytosol and in mitochondria, where the protein contributes to reducing the apoptotic death induced by hydrogen peroxide (H
Identifiants
pubmed: 36982977
pii: ijms24065903
doi: 10.3390/ijms24065903
pmc: PMC10058936
pii:
doi:
Substances chimiques
Resveratrol
Q369O8926L
Globins
9004-22-2
Nerve Tissue Proteins
0
Estrogen Receptor beta
0
Hydrogen Peroxide
BBX060AN9V
Gold
7440-57-5
Neuroglobin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Regione Lazio
ID : GeCoWEB n. A0375-2020- 36565
Organisme : Ministry of Education, Universities and Research
ID : PRIN 2017 n°2017SNRXH3
Organisme : Ministry of Education, Universities and Research
ID : ARTICOLO 1, COMMI 314-337 LEGGE 232/2016
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