Periphery Exploration around 2,6-Diazaspiro[3.4]octane Core Identifies a Potent Nitrofuran Antitubercular Lead.
2,6-diazaspiro[3.4]octane
antitubercular activity
azoles
diversity-oriented synthesis
molecular periphery
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
10 Mar 2023
10 Mar 2023
Historique:
received:
05
02
2023
revised:
07
03
2023
accepted:
07
03
2023
medline:
30
3
2023
entrez:
29
3
2023
pubmed:
30
3
2023
Statut:
epublish
Résumé
A small set of twelve compounds of a nitrofuran carboxamide chemotype was elaborated from a readily available 2,6-diazaspiro[3.4]octane building block, exploring diverse variants of the molecular periphery, including various azole substituents. The in vitro inhibitory activities of the synthesized compounds were assessed against
Identifiants
pubmed: 36985501
pii: molecules28062529
doi: 10.3390/molecules28062529
pmc: PMC10056547
pii:
doi:
Substances chimiques
octane
X1RV0B2FJV
Octanes
0
Antitubercular Agents
0
Nitrofurans
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Russian Foundation for Basic Research
ID : 21-53-12001
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