[Analysis of anti-SARS-CoV-2 IgG antibody titers after mRNA booster vaccination in patients with nonmalignant hematological disorders].
Aplastic anemia
Immune thrombocytopenic purpura
Pure red cell aplasia
SARS-CoV-2 mRNA vaccine
Journal
[Rinsho ketsueki] The Japanese journal of clinical hematology
ISSN: 0485-1439
Titre abrégé: Rinsho Ketsueki
Pays: Japan
ID NLM: 2984782R
Informations de publication
Date de publication:
2023
2023
Historique:
medline:
31
3
2023
entrez:
29
3
2023
pubmed:
30
3
2023
Statut:
ppublish
Résumé
In our facility, anti-SARS-CoV-2 mRNA vaccines were given to 21 patients, including 8 with aplastic anemia (AA), 3 with pure red cell aplasia (PRCA), and 10 with immune thrombocytopenic purpura (ITP), and IgG antibody titers were assessed one month after vaccinations. After receiving both a second vaccine and a booster shot, all patients with AA/PRCA treated with cyclosporine A aside from one, had IgG titers that were lower than the median levels of healthy controls. Even if prednisolone (PSL) doses did not go over 10 mg/day, ITP patients receiving PSL therapy were unable to achieve adequate levels of IgG after booster immunizations.
Identifiants
pubmed: 36990734
doi: 10.11406/rinketsu.64.133
doi:
Substances chimiques
Antibodies, Viral
0
Immunoglobulin G
0
Prednisolone
9PHQ9Y1OLM
RNA, Messenger
0
Types de publication
English Abstract
Journal Article
Langues
jpn
Sous-ensembles de citation
IM