WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction.

Frizzled Receptors / metabolism Ligands Signal Transduction Receptors, G-Protein-Coupled / metabolism Wnt Signaling Pathway Dishevelled Proteins / metabolism Phosphoproteins / metabolism

Journal

Science signaling
ISSN: 1937-9145
Titre abrégé: Sci Signal
Pays: United States
ID NLM: 101465400

Informations de publication

Date de publication:
04 04 2023
Historique:
medline: 6 4 2023
entrez: 4 4 2023
pubmed: 5 4 2023
Statut: ppublish

Résumé

Frizzleds (FZDs) are G protein-coupled receptors (GPCRs) that bind to WNT family ligands. FZDs signal through multiple effector proteins, including Dishevelled (DVL), which acts as a hub for several downstream signaling pathways. To understand how WNT binding to FZD stimulates intracellular signaling and influences downstream pathway selectivity, we investigated the dynamic changes in the FZD

Identifiants

DOI: 10.1126/scisignal.abo4974 PMID: 37014927
pubmed: 37014927
doi: 10.1126/scisignal.abo4974
doi:

Substances chimiques

Frizzled Receptors 0
Ligands 0
Receptors, G-Protein-Coupled 0
Dishevelled Proteins 0
Phosphoproteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabo4974

Auteurs

Carl-Fredrik Bowin (CF)

Department of Physiology and Pharmacology, Section of Receptor Biology and Signaling, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0001-9090-9493

Pawel Kozielewicz (P)

Department of Physiology and Pharmacology, Section of Receptor Biology and Signaling, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0003-1414-3566

Lukas Grätz (L)

Department of Physiology and Pharmacology, Section of Receptor Biology and Signaling, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0001-6755-0742

Maria Kowalski-Jahn (M)

Department of Physiology and Pharmacology, Section of Receptor Biology and Signaling, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0003-1442-3656

Hannes Schihada (H)

Department of Physiology and Pharmacology, Section of Receptor Biology and Signaling, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0002-1889-1636

Gunnar Schulte (G)

Department of Physiology and Pharmacology, Section of Receptor Biology and Signaling, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0002-2700-7013

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs Wnt › Récepteurs Frizzled › WNT stimulation induces dynamic conformational...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › WNT stimulation induces dynamic conformational...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › WNT stimulation induces dynamic conformational...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › WNT stimulation induces dynamic conformational...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Voie de signalisation Wnt › WNT stimulation induces dynamic conformational...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › Protéines Dishevelled › WNT stimulation induces dynamic conformational...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › WNT stimulation induces dynamic conformational...